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Dorsal Sural Nerve Test Sensitive to Oxaliplatin NeuropathyDorsal Sural Nerve Test Sensitive to Oxaliplatin Neuropathy

Dorsal sural nerve conduction testing is a moderately sensitive and very specific test for early detection of oxaliplatin-induced peripheral neuropathy and beats sural nerve testing. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Authors: González-Quevedo A, Santiesteban-Freixas R, Eells JT, Lima L, Sadun AA Abstract From 1991 to 1993, an epidemic of optic and peripheral neuropathy-the largest of the century-broke out in Cuba, affecting more than 50,000 people. Initially the main clinical features were decreased visual acuity, central and cecocentral scotomas, impaired color vision and absence of the papillomacular bundle. Later, peripheral and mixed optic-peripheral forms began to appear. Due to the magnitude of the epidemic, the Cuban government requested help from the international community at the 46th World Health Assembly in 19...
Source: MEDICC Review - Category: International Medicine & Public Health Tags: MEDICC Rev Source Type: research
It has been highlighted that the original article [1], published 21 February 2018, contained some errors in Table 3. This correction article shows the correct version of Table 3 and the changes that were made.
Source: Diabetology and Metabolic Syndrome - Category: Endocrinology Authors: Tags: Correction Source Type: research
TUESDAY, May 15, 2018 -- Childhood cancer survivors frequently have clinical abnormalities attributable to peripheral neuropathy, according to a study published online May 14 in JAMA Neurology. Tejaswi Kandula, M.B.B.S., from the University of New...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 7 May 2018 Source:Molecular Genetics and Metabolism Author(s): C.R. Ferreira, S.M.I. Goorden, A. Soldatos, M. Byers, J.M.M. Ghauharali-van der Vlugt, F.S. Beers-Stet, C. Groden, C.D. van Karnebeek, W.A. Gahl, F.M. Vaz, X. Jiang, H.J. Vernon Patients with primary serine biosynthetic defects manifest with intellectual disability, microcephaly, ichthyosis, seizures and peripheral neuropathy. The underlying pathogenesis of peripheral neuropathy in these patients has not been elucidated, but could be related to a decrease in the availability of certain classical sphingolipids, or to an increa...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Hereditary peripheral neuropathies comprise a heterogeneous spectrum of disorders, for which more than 100 different subtypes have been identified, with each having its own specific clinical characteristics, pathophysiology and prognosis [1,2]. In addition to length dependent neuropathies, there were several types of hereditary peripheral neuropathies with unusual symptoms, such as the central nerve system involvement in X-linked Charcot-Marie-Tooth disease [3,4], focal segmental glomerulosclerosis in INF2 mutations associated with dominant inherited intermediate Charcot-Marie-Tooth neuropathy [5], cardiomyopathy in heredi...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
(JAMA Network) A new study assesses chemotherapy-induced peripheral neuropathy in 121 long-term survivors of childhood cancer to detail clinical, functional, neurophysiological and patient-reported outcomes of the condition.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Abstract Sensory neurons of the dorsal root ganglia (DRG) are the primary responders to stimuli inducing feelings of touch, pain, temperature, vibration, pressure and muscle tension. They consist of multiple subpopulations based on their morphology, molecular and functional properties. Our understanding of DRG sensory neurons has been predominantly driven by rodent studies and using transformed cell lines, whereas less is known about human sensory DRG neurons simply because of limited availability of human tissue. Although these previous studies have been fundamental for our understanding of the sensory system, it...
Source: The International Journal of Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Int J Biochem Cell Biol Source Type: research
This cross-sectional study comprehensively assesses chemotherapy-induced peripheral neuropathy in childhood cancer survivors to define disease burden and functional effect and aims to inform screening recommendations.
Source: JAMA Neurology - Category: Neurology Source Type: research
Authors: Ozaki K, Terayama Y, Matsuura T, Narama I Abstract Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Male rats were divided into four groups: nondiabetic rats (N), alloxan-induced diabetic rats (AL), diabetic rats treated with an HFD (AH), and nondiabetic rats treated with an HFD (HF). Combined hyperglycemia and...
Source: Journal of Toxicologic Pathology - Category: Toxicology Tags: J Toxicol Pathol Source Type: research
The objective of this article is to summarize the current body of evidence describing NCS-1 and its interactions on a molecular and cellular scale, as well as describing macroscopic implications in physiology and medicine. Particular attention is paid to the role of NCS-1 in development and prevention of chemotherapy induced peripheral neuropathy (CIPN).
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
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