Dorsal Sural Nerve Test Sensitive to Oxaliplatin NeuropathyDorsal Sural Nerve Test Sensitive to Oxaliplatin Neuropathy

Dorsal sural nerve conduction testing is a moderately sensitive and very specific test for early detection of oxaliplatin-induced peripheral neuropathy and beats sural nerve testing. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Conclusions: The 500 µg methylcobalamin thrice weekly regime is more effective in increasing the serum cobalamin levels as compared to the 1500 µg methylcobalamin once weekly regime. PMID: 30013732 [PubMed]
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
Authors: Wang Z, Qi F, Cui Y, Zhao L, Sun X, Tang W, Cai P Abstract Numerous studies have indicated that in cancer treatment Chinese herbal medicines in combination with chemo-, radio-, or targeted-therapy can be used to enhance the efficacy of and diminish the side effects and complications caused by these therapies. Therefore, an understanding of Chinese herbal medicines is needed by physicians and other health care providers. This review provides an update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics. First, some Chinese herbal medicines (e.g. Astragalus, Ginseng, Scutellaria barb...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
Authors: Audet O, Bui HT, Allisse M, Comtois AS, Leone M Abstract Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neuromuscular disorder caused by the mutation of the SACS gene. Clinical symptoms of this disease include progressive ataxia, spasticity, and peripheral neuropathy. Similar to other neuromuscular disorders, these patients are prone to physical deconditioning which may lead to a loss of functional capacity. This paper aims to evaluate the impact of a training program on the physical fitness and the functional capacity of ARSACS patients. Twelve patients (age: 28.1 ± 8.2 yea...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
Publication date: Available online 17 July 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): David M. Walton, Stephen D. Minton, Alonzo D. CookAbstractThe Center for Disease Control (CDC) estimates that 29 million Americans have diabetes, and 70% of diabetic patients develop diabetic peripheral neuropathy [1,2]. Up to 27% of the direct medical cost of diabetes may be attributed to DPN [3]. A 2013 article from the American Diabetes Association reported a $176 billion direct medical cost of diabetes in 2012 [4]. DPN patients often suffer from shooting and burning pain in their distal limb...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Conclusions/SignificanceThe clinical characteristics of the two diseases should be considered in leprosy patients coinfected with HIV for better diagnosis and treatment of peripheral neuropathy. We suggest that new simplified assessment tools that allow the evaluation of the NFI of these patients be developed for use in the service.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
The prevalence of type 2 diabetes mellitus (T2DM), which results in many micro- and macrovascular complications with major morbidity, mortality, reduced quality of life and increased society costs, is rapidly increasing worldwide and is becoming a major global health issue [1 –3]. Diabetic foot ulcer (DFU), which is often associated with infection, peripheral neuropathy and peripheral arterial disease, is one of the most serious and problematic complications of diabetes and has been considered the most important predictor for lower-extremity amputations [4].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
The objective of this study was to analyze differences of postural characteristics between diabetics with peripheral neuropathy and diabetics without peripheral neuropathy. A learning effect of perturbation was found for diabetic peripheral neuropathy group in the posterior direction of perturbation during the first phase, which may indicate that it could be possible to design a postural control program for those people. PMID: 29996729 [PubMed - as supplied by publisher]
Source: International Journal of Occupational Safety and Ergonomics - Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research
Abstract It seems that histamine release in the site of neuronal injury could contribute to the neuropathic pain mechanism. In the present study, we investigated the anti-allodynic effects of chronic administration of different classes of histamine H1 and H2 receptor antagonists on neuropathic nociceptive behavior following tibial nerve transection (TNT) in rats. Peripheral neuropathy was induced by TNT surgery. We performed acetone tests (AT) to record cold allodynia, Von Frey tests (VFT) to measure mechanical allodynia, double plate test (DPT) to evaluate thermal place preference/avoidance and open field test (O...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Conclusions: The data for the first time revealed specific signaling pathways leading to BTZ-induced peripheral neuropathic pain, including the activation of mTOR and PI3K. Inhibition of these signal pathways alleviates pain. Targeting one or more of these signaling molecules may present new opportunities for treatment and management of peripheral painful neuropathy observed during chemotherapeutic application of BTZ.Cell Physiol Biochem 2018;48:54 –62
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
This study provides essential corroboratory evidence for CEP72 rs924607 and highlights the importance of drug transporter and inherited neuropathy genes in VIPN. This article is protected by copyright. All rights reserved. PMID: 29999516 [PubMed - as supplied by publisher]
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
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