Letter re: Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

I read with interest the practice guideline summary report for treatment of restless leg syndrome (RLS) in adults by the Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.1 Studies have shown a strong correlation between body iron stores, as determined by serum ferritin level, and the severity of RLS symptoms.2,3 Typically, in patients with RLS with ferritin level <50 mg/L, oral iron supplementation along with vitamin C, to help enhance iron absorption, is advised. How did the subcommittee arrive at a cutoff ferritin value of 75 mg/L? Can the subcommittee recommend how much iron supplementation is needed? What is the recommended ferritin level after supplementation? While studies looking at the efficacy of clonazepam for RLS symptoms may be lacking, giving it a Level U rating, there is ample anecdotal evidence attesting to its efficacy in RLS symptomatology.4
Source: Neurology - Category: Neurology Authors: Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research