Effcacy of Human Papillomavirus L1 Protein Vaccines (Cervarix and Gardasil) in Reducing the Risk of Cervical Intraepithelial Neoplasia: A Meta ‑analysis

This study aims to estimate the effcacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta ‑analysis. Relevant articles were identifed by two independent researchers searching international databanks. After application of inclusion/exclusion criteria and quality assessment, eligible articles were entered into the fnal meta‑analysis. Inverse variance method and fxed effect model were u sed to combine the results of the primary studies. The heterogeneity between the results was assessed using Cochrane andI2indices. Of 11,530 evidence identifed during the primary search, three papers were foundeligible for meta ‑analysis, including 7213 participants in the intervention groups and 7170 healthy controls. The effcacy (95% confdence interval) of HPV 6, 11, 16, 18 monovalent and quadrivalent vaccines against CIN 1, CIN 2, and CIN 3 were estimated as of 95% (88–98), 97% (85–99), and95% (78–99), respectively. This study showed that L1 protein vaccines Cervarix and Gardasil are highly protective vaccines playing an effective role in the prevention of HPV 6, 11, 16, 18 which are responsible for CIN 1, CIN 2, and CIN 3.Keywords:Cervical intraepithelial neoplasia, effcacy, human papillomavirus, meta ‑analysis, vaccine
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research