Characterisation of the faecal microbiota in Japanese patients with paediatric-onset primary sclerosing cholangitis

Dear Sir, Primary sclerosing cholangitis (PSC) is a liver disease often associated with IBD.1 Dysbiosis of the gut microbiota is implicated in PSC aetiology in adults,2–4 but less is known about paediatric-onset PSC. We analysed the faecal microbiota of 27 Japanese patients with paediatric-onset PSC as well as 16 age-matched patients with UC and 23 healthy controls (HCs) (see online S1) with pyrosequencing data of 16S rRNA gene V1-V2 region (accession #DRA004773). We assessed the influence of medications on the gut microbiota and found that salazosulfapyridine (SASP) treatment affected the microbiota structure with significant changes in the abundance of six major genera between the treated and untreated patients with PSC, perhaps due to its bactericidal property (see online S1). We thus report the analysis of 13 patients with PSC and 15 patients with UC and 23 HCs, all SASP untreated...
Source: Gut - Category: Gastroenterology Authors: Tags: Open access PostScript Source Type: research

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Publication date: Available online 20 February 2020Source: IDCasesAuthor(s): Heather L. Clark, Hugo E. Valencia, Jennifer J. Findeis-Hosey, Steve N. GeorasAbstractAspergillus molds are ubiquitous environmental molds that can cause devastating invasive infections in immunocompromised patients. These infections often go unrecognized in critically ill patients. This case describes a 68 year-old female resident of a long-term nursing facility with history of dementia, nonalcoholic fatty liver disease with cirrhosis, chronic kidney disease stage III and insulin-dependent type 2 diabetes who presented with vomiting, diarrhea and...
Source: IDCases - Category: Infectious Diseases Source Type: research
A heterogeneous liver pattern could indicate a higher risk for advanced cystic fibrosis liver disease
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Gastroenterology, Pathology, Pediatrics, Pulmonology, Radiology, Journal, Source Type: news
Authors: Chang JW, Lee HW, Kim BK, Park JY, Kim DY, Ahn SH, Han KH, Kim SU Abstract Background/Aims: The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting hepatic steatosis in patients with chronic hepatitis B (CHB) receiving AVT, compared with those not receiving AVT and in those with nonalcoholic fatty liver disease (NAFLD). Methods: Patients with CHB or NAFLD who unde...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Diagnostic Performance of Serum Asialo α1-Acid Glycoprotein Levels to Predict Liver Cirrhosis. Gut Liver. 2020 Feb 20;: Authors: Lim DH, Kim M, Jun DW, Kwak MJ, Yoon JH, Lee KN, Lee HL, Lee OY, Yoon BC, Choi HS, Kang BK Abstract Background/Aims: To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of serum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result. Methods: We conducted a case-control study o...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
THURSDAY, Feb. 20, 2020 -- A heterogeneous pattern on ultrasound examination of the liver may help identify children with cystic fibrosis (CF) at increased risk for developing advanced CF liver disease, according to a study published online Feb. 12...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conditions:   Cystic Fibrosis;   Liver Fibroses;   Cystic Fibrosis Liver Disease Intervention:   Sponsor:   Manchester University NHS Foundation Trust Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Race-based disparities are well documented in the entire spectrum of care for patients with chronic liver disease. The purpose of this study was to determine whether patient race impacts survival following transjugular intrahepatic portosystemic shunt (TIPS) creation for acute variceal bleeding.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 6 Source Type: research
Black patients are subject to documented disparities in the entire spectrum of chronic liver disease care, from screening to treatment and transplant organ access. Whether this racial inequity exists in access to endoscopy and/or transjugular intrahepatic portosystemic shunt (TIPS) creation is not known. We analyzed rates of endoscopy and TIPS during admissions for acute variceal bleeding in a national cohort.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 6 Source Type: research
Transjugular intrahepatic portosystemic shunt (TIPS) is an interventional radiology procedure to treat complications arising from portal hypertension in patients with liver disease. Postoperative survival following TIPS are dependent on several factors. This purpose of this study is to determine whether machine learning models can accurately predict in-hospital mortality following TIPS and ultimately, be used to develop a computational tool that can stratify patients based on their mortality risk.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 6 Source Type: research
Liver biopsy is the gold standard for diagnosing liver disease in patients undergoing evaluation for heart transplant. Obtaining an accurate assessment of the liver is crucial, as it predicts outcomes of heart transplantation. Transabdominal liver biopsy increases the risk of bleeding and can be dangerous due to the limited cardiac reserve of these patients, therefore transvenous approaches are preferable. Studies show that patients with congestive hepatopathy have heterogeneous involvement of the liver.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 22 Source Type: research
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