Recent Advances in the Field of Optical Coherence Tomography

AbstractPurpose of ReviewThe scope of this text is to critically review the most important recent advances in the field of optical coherence tomography, both from a clinical, scientific, and technical point of view.Recent FindingsIn recent years, important steps forward have been put in the field of optimization of PCI (with a focus on optimal sizing of stents and optimization of stent expansion after implantation) and the differentiation and its possible applications of various underlying morphologic characteristics of acute coronary syndrome lesions. Several efforts have been made to elucidate underlying mechanical causes of stent thrombosis, based on optical coherence tomography (OCT) imaging. This had led to the recognition of neoatherosclerosis as an important cause for very late stent thrombosis, fueling new research into this area and to the development of intracoronary devices which could be even more safe for patients on the very long term.SummaryWith an ever increasing use for clinical and scientific applications in coronary artery disease, OCT has come to a mature and solid tool in the armamentarium of the coronary artery disease specialist. With new areas deserving more intensified focus and several innovations ahead, it seems that OCT is there to defend its position as the standard intracoronary imaging modality for the next decennium.
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

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Authors: Hoffman H, Jalal MS, Chin LS Abstract Objective: We sought to identify risk factors for VTE following traumatic brain injury (TBI) and determine how venous thromboembolism (VTE) affects outcomes and costs using a national database. Methods: The Nationwide Inpatient Sample (NIS) was used to identify patients with TBI between 2002 and 2014. VTE was identified as any occurrence of deep venous thrombosis or pulmonary embolism. We investigated putative risk factors for VTE and determined the effect of VTE on outcomes including mortality and disposition. Results: 424,929 patients met the inclusion criteria. Ther...
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
Conclusion: This case demonstrates that catheter-based treatment of submassive pulmonary embolism restores hemodynamic stability and thus is an alternative to surgery or systemic thrombolysis, even in the pediatric setting. While catheter-directed thrombolysis is a safe and effective alternative to systemic thrombolysis, further research is needed to establish appropriate dosing and indications in the adolescent population. PMID: 31528140 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
In conclusion, even if it is still totally hypothetical, our point of view may have clinical consequences, especially when deciding to perform a liver biopsy in patients with a higher liver stiffness and suspending the anticoagulation in patients with PVT and no detectable prothrombotic factors. PMID: 31528244 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
A 44-year-old woman developed acute anuric renal failure in the context of septic shock after hysteroscopy and intrauterine device placement for abnormal uterine bleeding. Aminoglycoside and nonsteroidal anti-inflammatory drug use were likely contributing factors. In the past, she had had a deep venous thrombosis episode on oral contraception that led to a diagnosis of Factor V Leiden heterozygosity. Computed tomography with contrast of the abdomen and pelvis showed abnormal enhancement of the renal medulla, and the renal cortex did not take on contrast (Figure  1).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
ConclusionPortal and mesenteric venous thrombosis after laparoscopic sleeve gastrectomy is an unusual complication but it has life threatening consequences if it is not diagnosed early and treated adequately. The patients with porto-mesenteric venous thrombosis (PMVT) usually present themselves with vague abdominal symptoms. As so, the physicians should have high index of suspicion to recommend computed tomography (CT) abdomen to confirm diagnosis and start adequate treatment.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We have previously shown that abdominal aortic aneurysm (AAA) rupture occurs in regions of low wall shear stress, where flow recirculation and intraluminal thrombus (ILT) deposition predominate. We planned to analyze differential matrix metalloproteinase (MMP)12, and interleukin (IL)-6 levels in human AAA tissue. We hypothesized that AAA with higher ILT will have greater macrophage-mediated elastolytic activity, thus, contributing to the differential in sides of the AAA that rupture.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts from the 2019 Canadian Society for Vascular Surgery Annual Meeting Source Type: research
Studies have demonstrated that patients with peripheral arterial disease (PAD) are more prone to thrombotic events. However, the exact mechanism as to why this is the case is unknown. Therefore, we investigated the various regulatory proteins and coagulation factors involved in thrombus formation within a cohort of non-PAD and PAD patients.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts from the 2019 Canadian Society for Vascular Surgery Annual Meeting Source Type: research
Publication date: Available online 18 September 2019Source: Journal of Vascular and Interventional RadiologyAuthor(s): Tarub S. Mabud, David M. Cohn, Victoria A. Arendt, Gyeong-Sik Jeon, Xiao An, Jinxin Fu, Andre D. Souffrant, Anna M. Sailer, Rajesh Shah, David Wang, Daniel Y. Sze, William T. Kuo, Daniel L. Rubin, Lawrence V. HofmannAbstractPurposeTo study short-term and long-term outcomes of lower extremity venous stents placed at a single center and to characterize changes in vein diameter achieved by stent placement.Materials and MethodsA database of all patients who received lower extremity venous stents between 1996 a...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Abstract Pulmonary embolism (PE) is one of the most common causes of cardiovascular death. The most often PE etiology is a deep vein thrombosis (DVT) of the lower extremities, but embolic material can arise in pelvic or upper extremity veins as well as in right heart chambers. There is growing number of evidences of atrial fibrillation (AF) involvement in PE. The presence of AF in patients with PE may be both the cause and the consequence of PE. The PE association with AF should be considered in patients without confirmed DVT and with history of AF, which itself is associated with prothrombotic state. The valuable...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Objective: The blood of cancer patients is in a state of hypercoagulability, easily leading to thrombosis. Anemia is also a complication of tumors. Anemia and thrombosis affect the treatment of tumor patients. Methods: Ginsenosides Rb were extracted from the stems and leaves of American ginseng using water-saturated ethanol and ethyl acetate in silica gel column. Tumor mice model was established by injecting H22 hepatocellular carcinoma cells into the axilla of mice. Mice were randomly divided into 6 groups: normal control group, model control group, positive control group, low dose group (7 mg/kg), ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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