Progesterone Receptor Signaling in Uterine Myometrial Physiology and Preterm Birth.
Discussions include novel conceptual discoveries and new development in legacy pathways such as the signal transducers NF-κB, ZEB, microRNA, and the unfolded protein response pathways. We also discuss the impact of progesterone receptor isoform composition and ligand accessibility in modification of the progesterone receptor genomic actions. PMID: 28527571 [PubMed - in process]
Date: Tuesday, 05 28, 2019; Speaker: Dr. Thuy Ngo, Research Assistant Professor, Oregon Health and Science University; Building 29B; 1H10
Prenatal fever could result in brain function impairments in the offspring. The present study investigated the effect of interleukin-6 (IL-6)-induced maternal fever on the offspring and the involvement of connexin 36 in this process. Pregnant C57BL/6J mice were injected with IL-6 on gestational day 15. The levels of iNOS and COX-2 were measured as an index of neuroinflammation in the brain of newborn pups. Offspring were treated with the connexin 36 (Cx36) inhibitor mefloquine at postnatal day (P)1 –P3 or at P40–P42. Rotarod, grip traction, and foot fault tests were carried out to evaluate the motor behavior of...
In conclusion, HCQ did not adversely affect placental tissue and may have a protective anti-inflammatory function. Further research is needed to determine the mechanisms of HCQ actions on human placenta and whether they could be utilized to improve pregnancy outcomes.
Publication date: Available online 20 May 2019Source: Reproductive ToxicologyAuthor(s): Xin Hu, Shuzhao Li, Piera M. Cirillo, Nickilou Y. Krigbaum, ViLinh Tran, Dean P. Jones, Barbara A. CohnAbstractHigh-resolution metabolomics (HRM) profiling of metabolic fingerprints can improve understanding of how poly and perfluoroalkyl substances (PFASs) induce metabolic alterations of in utero environment and impact fetal health. HRM profiling and quantification of PFASs were performed for 397 maternal perinatal serum samples collected from 1959-1967 in the Child Health and Development Studies (CHDS). We used Metabolome-Wide Associa...
[Citizen] Kibondo -Pregnant women giving birth outside health facilities in Kibondo District, Kigoma Region face a fine of between Sh20, 000 and Sh50, 000.
Conditions: Medical Nutrition Therapy; Gestational Diabetes Mellitus; Adverse Pregnancy Outcomes; Fasting Plasma Glucose; HbA1c; Gestational Weight Gain Interventions: Dietary Supplement: Enteral Nutrition Suspension (TFP-DM); Behavioral: Medical Nutrition Therpay Sponsors: Capital Medical University; Zhejiang University School of Medicine, Obstetrics and Gynecology Hospital; Nutricia Pharmaceutical Co., Ltd. Recruiting
Conclusions/Implications for Practice: In the aftermath of fetal death, health professionals should use insightful and empathic communication skills to help mothers cope with their loss. In addition, some of the participants wanted to see their babies, and some did not. Thus, individualized care is very important for women who experience pregnancy loss.
Chemotherapy performed on women during pregnancy could adversely affect long-term...Read more on AuntMinnie.comRelated Reading: MRI brain scans show benefits of prenatal folic acid Fetal MRI can spot early brain abnormality MRI shows maternal depression meds affect babies' brains MRI links blood flow to brain development in preterm babies MRI scans during 1st trimester of pregnancy are safe
Day three of APA ’s Annual Meeting included a call to psychiatrists to lead in efforts to improve the lives of children, the release of APA poll results showing mental health stigma remains a major challenge in the workplace, and conversation around the ways psychiatrists can help people of differing political bac kgrounds find common ground.Through May 22,Psychiatric News will deliver an evening digest of important highlights from the meeting.Kellogg CEO Urges Psychiatrists to Advocate for Trauma-Informed Care for ChildrenDuring the William C. Menninger Memorial Lecture on Monday, La June Montgomery Tabron called on...
Most doctors agree that, in most cases, it is safe to masturbate while pregnant. In this article, we look at some of the myths and misconceptions that surround masturbation during pregnancy.