Progesterone Receptor Signaling in Uterine Myometrial Physiology and Preterm Birth.
Discussions include novel conceptual discoveries and new development in legacy pathways such as the signal transducers NF-κB, ZEB, microRNA, and the unfolded protein response pathways. We also discuss the impact of progesterone receptor isoform composition and ligand accessibility in modification of the progesterone receptor genomic actions. PMID: 28527571 [PubMed - in process]
Authors: Roque M, Bianco B, Christofolini DM, Cordts EB, Vilarino FL, Carvalho W, Valle M, Sampaio M, Geber S, Esteves SC, Barbosa CP Abstract Controlled ovarian stimulation (COS) is crucial for optimizing in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) success. Multiple factors influence the ovarian response to COS, making predictions about oocyte yields not so straightforward. As a result, the ovarian response may be poor or suboptimal, or even excessive, all of which have negative consequences for the affected patient. There is a group of patients that present with a suboptimal response to...
Authors: Makrigiannakis A, Vrekoussis T, Zoumakis E, Hatzidakis V, Vlachou E, Salakos N, Kalantaridou SN Abstract Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal-fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent...
Binucleate trophoblast giant cells (TGCs) are one characteristic feature of the ruminant placenta. In cows, the frequency of TGCs remains constant for most of the duration of pregnancy. As TGCs are depleted by their fusion with uterine epithelial cells, they need to be constantly formed. It is still unclear whether they develop from stem cells within the trophectoderm or whether they can arise from any uninucleate trophoblast cell (UTC). Within the latter, generally accepted theory, a basally located uninucleate cell (BUC) without contact to the feto-maternal interface would represent a transient cell between a UTC and a T...
Comment on "The influence of palatable high-energy diet in diet-induced obesity pregnant rats on offspring oxidative stress in liver". Eur Rev Med Pharmacol Sci. 2018 Jun;22(11):3275-3276 Authors: Brunelli V, Perillo P, Milione S PMID: 29917218 [PubMed - in process]
CONCLUSIONS: Overall, MDFP-AL is more effective and safe than FG for the treatment of IDA in pregnant women. PMID: 29917215 [PubMed - in process]
CONCLUSIONS: HOTTIP was lowly expressed in preeclampsia and was able to suppress the progression of preeclampsia. PMID: 29917176 [PubMed - in process]
(Reuters Health) - Using non-steroidal anti-inflammatory drugs (NSAIDs) around the time of conception significantly increases the risk of miscarriage in the first eight weeks of pregnancy, a study suggests.
Increased risk of neonatal readmission and major malformations for lithium - exposed pregnancy
Conditions: Carcinoma; Ovarian Neoplasm; Endocrine Gland Neoplasm; Urogenital Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases; Gona dal Disorders; Genital Neoplasm, Female; Neoplasms, Glandular and Epithelial Intervention: Dietary Supplement: Ocoxin-Viusid Sponsor: Catalysis SL Not yet recruiting