Host cell autophagy promotes BK virus infection.

Host cell autophagy promotes BK virus infection.
Virology. 2014 May;456-457C:87-95
Authors: Bouley SJ, Maginnis MS, Derdowski A, Gee GV, O׳Hara BA, Nelson CD, Bara AM, Atwood WJ, Dugan AS
Abstract
Autophagy is important for a variety for virus life cycles. We sought to determine the role of autophagy in human BK polyomavirus (BKPyV) infection. The addition excess amino acids during viral infection reduced BKPyV infection. Perturbing autophagy levels using inhibitors, 3-MA, bafilomycin A1, and spautin-1, also reduced infection, while rapamycin treatment of host cells increased infection. siRNA knockdown of autophagy genes, ATG7 and Beclin-1, corresponded to a decrease in BKPyV infection. BKPyV infection not only correlated with autophagosome formation, but also virus particles localized to autophagy-specific compartments early in infection. These data support a novel role for autophagy in the promotion of BKPyV infection.
PMID: 24889228 [PubMed - as supplied by publisher]

Source: Virology - May 1, 2014 Category: Virology Authors: Bouley SJ, Maginnis MS, Derdowski A, Gee GV, O׳Hara BA, Nelson CD, Bara AM, Atwood WJ, Dugan AS Tags: Virology Source Type: research