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Heterogeneous Lab Ref Values Hamper Dx of Pediatric Celiac Disease Heterogeneous Lab Ref Values Hamper Dx of Pediatric Celiac Disease

Heterogeneous upper limits of normal for anti-tissue transglutaminase (anti-tTG) hamper the diagnosis of pediatric celiac disease using the revised ESPGHAN (European Society for Pediatric Gastroenterology, Hepatology and Nutrition) guidelines, according to a new survey.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pediatrics News Source Type: news

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Publication date: Available online 17 February 2018 Source:The Journal of Molecular Diagnostics Author(s): Michael Erlichster, Jason A. Tye-Din, Michael D. Varney, Efstratios Skafidas, Patrick Kwan Human leukocyte antigen (HLA) genotyping has become a useful investigation in the diagnostic work-up of coeliac disease (CD), with utility in risk stratification and screening. However, broad application of this technology has been hindered by the cost and time burden of conventional laboratory-based assays. We have developed and validated CD–loop-mediated isothermal amplification (CD-LAMP), a LAMP assay, which enables ra...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
After being diagnosed with celiac disease as an adult, I was told very little other than to follow a gluten-free diet. Here are 10 things I wish my doctor had told me upon diagnosis.Medscape Nurses
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nursing Article Source Type: news
Publication date: 15 July 2018 Source:Food Chemistry, Volume 254 Author(s): Haili Li, Keren Byrne, Renata Galiamov, Omar Mendoza-Porras, Utpal Bose, Crispin A. Howitt, Michelle L. Colgrave A strict, lifelong gluten-free (GF) diet is currently the only treatment for coeliac disease (CD). Vinegar and soy sauce are fermented condiments that often include wheat and/or barley. During fermentation cereal proteins are partially degraded by enzymes to yield peptide fragments and amino acids. Whether these fermented products contain intact or degraded gluten proteins and if they are safe for people with CD remains in question. LC-...
Source: Food Chemistry - Category: Food Science Source Type: research
Conditions:   Development and Validation of Gut Permeability Sensor;   Permeability; Increased;   Celiac Disease;   Inflammatory Bowel Diseases;   Liver Diseases;   HIV/AIDS Intervention:   Diagnostic Test: Spectroscopic gut permeability test Sponsor:   Imperial College London Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Conclusions: These results demonstrated that patients (children) with Down syndrome had high prevalence of CD (more than one in twenty). The prevalence is high enough to motivate screening CD in DS children. PMID: 29435186 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Abstract Enteropathy‐associated T‐cell lymphoma is regarded as a dismal, late complication of coeliac disease, though a single case of T‐cell lymphoma with such features arising in the setting of autoimmune enteropathy of the adult has been reported to date. We aim to describe the case of a 41‐year‐old woman complaining of severe malabsorption syndrome, who was diagnosed with autoimmune enteropathy based on the presence of flat intestinal mucosa unresponsive to any dietary restriction and positivity for enterocyte autoantibodies. Steroid therapy led to a complete recovery of both mucosal and clinical findings ove...
Source: Hematological Oncology - Category: Hematology Authors: Tags: CASE REPORT Source Type: research
ConclusionsA GFD alters certain cardiovascular risk factors in patients with celiac disease, but the overall effect on cardiovascular risk is unclear. Further studies are warranted.
Source: Journal of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Meta Analysis and Systematic Review Source Type: research
(Reuters Health) - People with celiac disease who are extremely vigilant about not ingesting gluten may perceive that their quality of life is reduced, according to a new study.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
AbstractAimTo investigate the association of alleles of the 3 ′ immunoglobulin heavy-chain regulatory region 1 (3′RR-1) enhancer hs1.2 in patients with type 1 diabetes (T1D).MethodsEighty-one patients with T1D [among which 12 had concomitant coeliac disease (CD) and 25 an autoimmune thyroid disease (AITD)] were compared to 248 healthy individuals. All subjects were recruited from the same geographical area. Blood samples were collected from all patients and a nested PCR was performed to amplify the core of the 3 ′RR-1 and detect the alleles of the hs1.2 enhancer.ResultsAllele distribution in healthy indiv...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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