Male infertility could raise the risk of testicular cancer
Researchers from Lund University in Sweden found infertile men are likely to suffer from a deficiency of the hormone testosterone. This may increase the risk of testicular cancer.
In a large Australian study, researchers found that baby boys born with undescended testes had a higher risk of health problems like infertility and cancer, especially if corrective surgery was delayed.
To analyze the sperm proteome of patients with testicular cancer non-seminoma (TCNS) before cancer treatment and identify proteins responsible for the altered reproductive function.
Boys born with undescended testes had 2.4 times the risk of adult testicular cancer compared to other boys, the University of Sydney researchers reported.
FRIDAY, Aug. 31, 2018 -- Young boys with undescended testes are at increased risk for testicular cancer and infertility in adulthood, new research suggests. Undescended testes are the most common birth defect in infant boys, affecting one in 100....
(University of Sydney) Medical researchers are urging greater compliance with guidelines recommending surgery for undescended testes (UDT) before 18 months of age following new evidence that UDT more than doubles the risk of testicular cancer and increases infertility in adult males.
CONCLUSIONS Results of this study suggest that ozone therapy, either as a single agent or in combination with hCG, is a promising approach for protection of testicular functions. PMID: 30130360 [PubMed - in process]
. Stadler There is a correlation between cryptorchidism and an increased risk of testicular cancer and infertility. During orchidopexy, testicular biopsies are performed to confirm the presence of type A dark (Ad) spermatogonia, which are a marker for low infertility risk (LIR). The Ad spermatogonia are absent in high infertility risk (HIR) patients, who are treated with a gonadotropin-releasing hormone agonist (GnRHa) to significantly lower the risk of infertility. Despite its prevalence, little is known about the molecular events involved in cryptorchidism. Previously, we compared the transcriptomes of LIR versus HIR...
Purpose of review Although platinum-based chemotherapy (CHT) remains the cornerstone of clinical stage I testicular germ cell tumor (GCT) treatment, its long-term toxicity and complications in cancer survivors are unclear. Recent findings Cardiovascular disease and secondary malignancies represent the most life-threatening long-term complications and typically occur 10 years after treatment. Other potential intermediate deleterious effects include pulmonary toxicity, ototoxicity, neurotoxicity, hypogonadism and infertility. The incidence and time to onset vary according to patients’ genetic susceptibility, CHT r...
ConclusionIn cases of TML incidental finding by US with the presence of risk factors (personal history of testicular cancer, testicular atrophy, infertility, cryptorchidism) a consultation with a specialist should be considered. In the absence of risk factors, the occurrence of testicular cancer in patients with TML is similar to the risk of the general population.
CONCLUSIONS: There is an increasing demand for fertility preservation, especially from patients with benign disease. Only a small proportion of men utilised their banked sperm, however, those that did had a good chance of becoming fathers. Data from this study will be used to review our referral pathways and inform our future practice. PMID: 29944041 [PubMed - in process]