The Tryptophan-Kynurenine Pathway, Systemic Inflammation, and Long-Term Outcome after Kidney Transplantation.
CONCLUSIONS: Of tryptophan metabolites, serum 3-hydroxykynurenine is cross-sectionally most strongly and consistently associated with systemic inflammation and prospectively with adverse long-term outcome after kidney transplantation. Serum 3-hydroxykynurenine may be an interesting biomarker and target for the evaluation of drugs interfering in the tryptophan-kynurenine pathway.
PMID: 28490533 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: de Vries LV, Minovic I, Franssen CF, van Faassen M, Sanders JF, Berger SP, Navis G, Kema IP, Bakker SJ Tags: Am J Physiol Renal Physiol Source Type: research
More News: Kidney Transplant | Kidney Transplantation | Transplant Surgery | Transplants | Urology & Nephrology