Role of Δ133p53 isoform in NF-κB inhibitor PDTC-mediated growth inhibition of MKN45 gastric cancer cells.

CONCLUSION: Δ133p53 isoform (not p53β) is required in PDTC-induced inhibition of MKN45 gastric cancer cells, indicating that disturbance in the cross-talk between p53 and NF-κB pathways is a promising target in pharmaceutical research for the development of treatment strategies for gastric cancer.
PMID: 28487608 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - April 21, 2017 Category: Gastroenterology Authors: Zhang HM, Sang XG, Wang YZ, Cui C, Zhang L, Ji WS Tags: World J Gastroenterol Source Type: research