Significance of Tumor-Infiltrating Lymphocytes and the Expression of Topoisomerase II α in the Prediction of the Clinical Outcome of Patients with Triple-Negative Breast Cancer after Taxane-Anthracycline-Based Neoadjuvant Chemotherapy

Conclusion: Our study demonstrated that CD4+ TILs and TOPOII α in pretreated cancer tissues were significantly correlated with CD8+ TILs. CD4+ TILs, CD8+ TILs, and TOPOIIα expression were predictors of pCR and 5-year DFS of TNBC patients who were treated with NAC, and TOPOIIα was an independent predictor of pCR. CD8+ TILs were a key factor in the predictio n of good 5-year OS rates of TNBC patients after taxane-anthracycline-based NAC.Chemotherapy 2017;62:246-255
Source: Chemotherapy - Category: Cancer & Oncology Source Type: research