Postdoc positions on context dependent cell signalling (wet and/or dry)

Why do some mutationscause cancer in some tissues and not others ? What happens to the cell signalling pathways during differentiation ? Why are some genes essential in some cell types and not others or why are some drugs more effective atkilling some cell types than others?We think that this is a great time to be asking these questions of how the genetic background or tissue of origin changes cell states. More precisely for us, how this re-wires cell signalling. It has become routine to measure changes in phosphorylation across different conditions, including different cancer types. The Sanger and others are establishing panels of human cell lines that are being profiled with an increasing array of omics technologies with drug sensitivity and CRISPR based gene essentiality information. These panels offer a great opportunity to address these questions.We want to combine the work we have been doing in studyinghuman signalling with phosphoproteomic data, withvariant effect predictors, microscopy based studies of cell signalling and network modelling to address this question of context dependent changes in cell signalling.To support this research we have 2 postdoc positions available: one would be primarily computational and would involve image analysis and network modelling in collaboration with microscopy groups (see here for project and application); the second would be primarily experimental with a focus on microscopy. The latter would be available via the ESPOD fellowship s...
Source: Evolution of Cellular Networks - Category: Cytology Tags: positions Source Type: blogs