Immunogenicity to poliovirus type 2 following two doses of fractional intradermal inactivated poliovirus vaccine: A novel dose sparing immunization schedule.

DISCUSSION: Overall, two fIPV doses are more immunogenic than a single full-dose, associated with significantly increased seroconversion rates and antibody titers. Two fIPV doses together use two-fifth of the vaccine compared to one full-dose IPV. In response to the current IPV shortage, a schedule of two fIPV doses at ages 6 and 14weekshas been endorsed by technical oversight committees and has been introduced in some affected countries. PMID: 28434691 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28434691?dopt=Abstract

Source: Vaccine - April 20, 2017 Category: Allergy & Immunology Authors: Anand A, Molodecky NA, Pallansch MA, Sutter RW Tags: Vaccine Source Type: research