Keloid development: New genes identified may unlock its mystery
Previously unidentified genes that may be responsible for keloid scarring have been uncovered by researchers, a discovery that could unlock the mystery of keloid development and provide insight for more effective treatment. Keloid scars form raised, firm skin areas that may become itchy, tender, and painful. Unlike regular scars, keloids do not subside over time and often extend outside the wound site. Keloids most often occur on the chest, shoulders, earlobes (following ear piercing), upper arms and cheeks.
Publication date: Available online 30 March 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Stefanie H. Meeuwis, Henriët van Middendorp, Antoinette I.M. van Laarhoven, Cora van Leijenhorst, Gustavo Pacheco-Lopez, Adriana P.M. Lavrijsen, Dieuwke S. Veldhuijzen, Andrea W.M. Evers
(HAMBURG, Pa.) — The spring breezes of 2020 are carrying more than just tree pollen. There’s a whiff of paranoia in the air. For millions of seasonal allergy sufferers, the annual onset of watery eyes and scratchy throats is bumping up against the global spread of a new virus that produces its own constellation of respiratory symptoms. Forecasters are predicting a brutal spring allergy season for swaths of the U.S. at the same time that COVID-19 cases are rising dramatically. That’s causing angst for people who never have had to particularly worry about their hay fever, other than to stock up on antihista...
Condition: Keloid Interventions: Biological: Umbilical Cord-Mesenchymal Stem Cells and Conditioned Medium; Biological: Conditioned Medium; Biological: Triamcinolone Acetonide Sponsor: PT. Prodia Stem Cell Indonesia Not yet recruiting
Conditions: Atopic Dermatitis; Pruritus; Pruritus Chronic; Dermatitis Interventions: Drug: Naltrexone; Other: Placebo Sponsor: University of Minnesota Not yet recruiting
Conclusion: The results of this study lay the foundation for our future research, which includes an international Delphi study among many scar experts, and an international focus group study among scar patients, aiming to elucidate how scar quality must be defined and measured from both professional and patient perspectives.
Abnormal scarring, manifesting as hypertrophic or keloid scars, affects millions of people every year after surgeries, injury, and even as residual from skin disease. These overgrown scars can be painful, itchy, and often disfiguring. Although many treatments for abnormal scars exist, they are often invasive and do not prevent scar recurrence. Spherical nucleic acids (SNAs) are nanoparticle-oligonucleotide conjugates consisting of a nanoparticle core and dense shell of oriented oligonucleotides.
Keloids are exuberant scars which extend beyond the borders of the inciting cutaneous injury, they can be disfiguring, pruritic and/or painful and can cause significant impairment of quality of life (QoL). However, little research has been done to assess the burden of keloids on QoL. Our aim was to assess how severely keloids affect QoL and identify whether symptomatology (pain, itch) was associated with the severity of QoL impairment, using patient-reported measures of symptoms and quality of life.
This article is protected by copyright. All rights reserved. PMID: 30101410 [PubMed - as supplied by publisher]
Conclusions: β-Blockers may be an effective alternative modality for preventing and treating keloids and hypertrophic scars. Large-scale multicenter prospective studies that use histology to diagnose scars and diagnose the postoperative scars at the most suitable period are needed to confirm the effectiveness of blockers for abnormal scars. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
This study evaluated the association of keloid disease with health-related quality of life (HRQL) and identified indicators of burden using a cross-sectional survey study, with 1 disease-specific HRQL measure (Skindex-29) and 2 generic HRQL measures (SF-36 and EQ-5D-5L). A total of 106 keloid patients with no other skin diseases participated in the study. Having keloid disease was associated with a considerable impairment of emotional wellbeing, with most impairment on the emotional and mental HRQL. Pain and itch were the strongest indicators of HRQL impairment in keloid patients. Having painful or itchy keloids was relate...