Correcting Postprandial Hyperglycemia in Zucker Diabetic Fatty Rats With an SGLT2 Inhibitor Restores Glucose Effectiveness in the Liver and Reduces Insulin Resistance in Skeletal Muscle

In conclusion, SGLT2-I treatment improves impaired glucose effectiveness in the liver and insulin sensitivity in muscle by eliminating glucotoxicity, which reinstates metabolic flexibility with restored preprandial lipid oxidation and postprandial glucose flux in ZDF rats.

Source: Diabetes - April 20, 2017 Category: Endocrinology Authors: OBrien, T. P.; Jenkins, E. C.; Estes, S. K.; Castaneda, A. V.; Ueta, K.; Farmer, T. D.; Puglisi, A. E.; Swift, L. L.; Printz, R. L.; Shiota, M. Tags: Metabolism Source Type: research