Distinct white matter alterations following severe stroke: Longitudinal DTI study in neglect

Conclusions:
The present data show how stroke entails global alterations of lesion-spared network architecture over time. Sufficiently large lesions of widely interconnected association cortex induce distinct, large-scale structural reorganization in domain-specific network connections. Besides their relevance to unrecovered domain-specific symptoms, these effects might also explain mechanisms of domain-general deficits in stroke patients, pointing to potential targets for therapeutic intervention.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Umarova, R. M., Beume, L., Reisert, M., Kaller, C. P., Klöppel, S., Mader, I., Glauche, V., Kiselev, V. G., Catani, M., Weiller, C. Tags: Volumetric MRI, Neglect, Plasticity, Infarction ARTICLE Source Type: research