A randomised controlled trial of CPAP versus non-invasive ventilation for initial treatment of obesity hypoventilation syndrome

Conclusions In newly diagnosed severe OHS, Bi-level PAP and CPAP resulted in similar improvements in ventilatory failure, HRQoL and adherence. Baseline PaCO2 predicted persistent ventilatory failure on treatment. Long-term studies are required to determine whether these treatments have different cost-effectiveness or impact on mortality. Trial registration number ACTRN12611000874910, results.

http://thorax.bmj.com/cgi/content/short/72/5/437?rss=1

Source: Thorax - April 10, 2017 Category: Respiratory Medicine Authors: Howard, M. E., Piper, A. J., Stevens, B., Holland, A. E., Yee, B. J., Dabscheck, E., Mortimer, D., Burge, A. T., Flunt, D., Buchan, C., Rautela, L., Sheers, N., Hillman, D., Berlowitz, D. J. Tags: Clinical trials (epidemiology), Epidemiologic studies, Health education, Obesity (public health) Non-invasive ventilation Source Type: research