An anti-mycobacterial bisfunctionalized sphingolipid and new bromopyrrole alkaloid from the Indonesian marine sponge Agelas sp.

AbstractIn the course of our studies on anti-mycobacterial substances from marine organisms, the known dimeric sphingolipid, leucettamol A (1), was isolated as an active component, together with the new bromopyrrole alkaloid, 5-bromophakelline (2), and twelve known congeners from the Indonesian marine spongeAgelas sp. The structure of2 was elucidated based on its spectroscopic data. Compound1 and its bis TFA salt showed inhibition zones of 12 and 7  mm againstMycobacterium smegmatis at 50  μg/disk, respectively, while theN,N ’-diacetyl derivative (1a) was not active at 50  μg/disk. Therefore, free amino groups are important for anti-mycobacterial activity. This is the first study to show the anti-mycobacterial activity of a bisfunctionalized sphingolipid. Compound13 exhibited weak PTP1B inhibitory activity (29% inhibition at 35  μM).
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research