Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning.

CONCLUSIONS: None of the models perfectly described the experimental data. Important factors like the variable degree of protein binding by VPA could not be included in the models. The small number of subjects used in the study made the analysis of more covariates impossible. PMID: 28187395 [PubMed - indexed for MEDLINE]

https://www.ncbi.nlm.nih.gov/pubmed/28187395?dopt=Abstract

Source: Pharmacological Reports - March 24, 2017 Category: Drugs & Pharmacology Authors: Jawień W, Wilimowska J, Kłys M, Piekoszewski W Tags: Pharmacol Rep Source Type: research