Development of anticancer agents targeting the Hedgehog signaling.

Development of anticancer agents targeting the Hedgehog signaling. Cell Mol Life Sci. 2017 Mar 17;: Authors: Zhang X, Tian Y, Yang Y, Hao J Abstract Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment. PMID: 28314894 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research