Society partner Pfizer introduces 2017 ASPIRE Young Investigator Research Awards in Endocrinology

The mission of the 2017 Global ASPIRE Young Investigator Research Awards in Endocrinology is to advance the medical knowledge of the fundamental mechanisms of disease, mechanisms of action of current and potential future treatments, and to improve the care of patients with endocrine disorders.Pfizer invites junior investigators to apply for the 2017 Global ASPIRE Young Investigator Research Awards in Endocrinology from6 March 2017. Funding will be provided to research proposals that seek to explore translational or clinical research in the area of endocrine disease in children and young adults to address:Morbidity and mortality in Adult Growth Hormone Deficiency or AcromegalyImpact and/or needs of the patient with Growth Disorders during the pediatric and transitional years/young adult lifeNovel strategies including Quality of Life and Patient Reported Outcomes to evaluate and treat acromegaly or Adult Growth Hormone Deficiency.Early diagnosis and treatment of Adult Growth Hormone Deficiency or AcromegalyFind out more on thePfizer website.Deadline2 June 2017.Pfizer is a corporate partner of the Society for Endocrinology. See further information about our corporate supporters.
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Chloe Powell, a 26-year-old midwife from Bristol, developed acromegaly because of a benign brain tumour, which made her hands and feet grow uncontrollably, and her facial features swell up.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Source: JDDG - Category: Dermatology Authors: Source Type: research
Authors: Mercado M, Ramírez-Rentería C Abstract Diabetes is recognized as one of the most common acromegaly co-morbidities with a prevalence ranging 20-53%, while over one-third of these patients have an altered lipid profile. In fact, as in the non-acromegalic population, carbohydrate and lipid metabolism abnormalities are closely linked. Long term exposure to an excess of growth hormone (GH) and Insulin-like growth factor-1 concentrations results in insulin resistance and an increased hepatic glucose production. The lipolytic effect of GH results in the mobilization of free fatty acids that further ...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
Source: Endocrine - Category: Endocrinology Source Type: research
The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and acromegaly. Thirty-one patients with acromegaly, 28 patients with prolactinoma, and 33 healthy individuals were included in the study. Serum concentrations of RANKL, OPG, bone alkaline phosphatase (bone ALP), osteocalcin (OC), C-terminal telopeptide of type 1 collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP)...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
J. A. Goldbogen and P. T. Madsen The extant diversity and rich fossil record of cetaceans provides an extraordinary evolutionary context for investigating the relationship between form, function and ecology. The transition from terrestrial to marine ecosystems is associated with a complex suite of morphological and physiological adaptations that were required for a fully aquatic mammalian life history. Two specific functional innovations that characterize the two great clades of cetaceans, echolocation in toothed whales (Odontoceti) and filter feeding in baleen whales (Mysticeti), provide a powerful comparative framework ...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: COMMENTARY Source Type: research
Conclusions Excessive growth hormone secretion persisting after pituitary surgery and irradiation can be controlled in a convenient way for the patient with acromegaly by combining monthly lanreotide and weekly pegvisomant injections, if monotherapy with a somatostatin analog fails. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes Reports - Category: Endocrinology Authors: Tags: Case Report Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0629-9223 Purpose Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. Methods We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. On the basis of availability of pathological specimen of thyroid tissues,...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research
Condition:   Acromegaly Interventions:   Drug: IONIS-GHR-LRx;   Drug: Placebo Sponsor:   Ionis Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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