Nuclear Import of JAK1 Is Mediated by a Classical NLS and Is Required for Survival of Diffuse Large B-cell Lymphoma

This study demonstrates that the nuclear import of JAK1 is essential for the optimal fitness of ABC DLBCL cells, and targeting JAK1 nuclear localization is a potential therapeutic strategy for ABC DLBCL. Mol Cancer Res; 15(3); 348–57. ©2016 AACR.

Source: Molecular Cancer Research - February 27, 2017 Category: Cancer & Oncology Authors: Zhu, F., Hwang, B., Miyamoto, S., Rui, L. Tags: Signal Transduction Source Type: research