Alloimmunization in autoimmune hemolytic anemia patient: The differential adsorption approach

In this report, we present our approach in a thalassemia patient who presented with warm-type autoimmune hemolytic anemia, low hemoglobin of 5.8 g/dl, and three significant alloantibodies (anti-D, anti-S, and anti-Jk b) which were masked by pan-reactive warm autoantibody(s). Differential adsorption was used to unmask underlying alloantibodies. We suggest that differential adsorption procedure is an effective and efficient method for autoantibody adsorption, detection, and identification of masked alloantibody(s), especially in patients with low hemoglobin and history of recent blood transfusion.

Source: Asian Journal of Transfusion Science - February 21, 2017 Category: Hematology Authors: Ravi C Dara Aseem Kumar Tiwari Dinesh Arora Subhasis Mitra Devi Prasad Acharya Geet Aggarwal Jyoti Sharma Source Type: research