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Lupus Studies Point to Gut Microbes, EpigeneticsLupus Studies Point to Gut Microbes, Epigenetics

Intestinal 'microbiome' and epigenetic changes in gene expression might contribute to systemic lupus erythematosus and could offer new routes to therapy, new studies have suggested. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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Ze Xiu Xiao, Xu Zheng, Li Hu, Julie Wang, Nancy Olsen, Song Guo Zheng
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion Sjögren Syndrome (SS) is named for Swedish ophthalmologist Henrik Sjögren who published a case series in 1933 describing patients with dry eyes and arthritis. SS is a “chronic autoimmune inflammatory exocrinopathy” that is characterized by lymphocytic infiltration of the lacrimal and salivary glands and has various degrees of systematic involvement. Keratoconjunctivitis sicca and xerostomia are the main clinical symptoms. Sicca is a Latin word meaning dry. Dryness of the eyes and mouth without evidence of autoimmune disease is called Sicca syndrome or Sicca complex. SS can be primary or se...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Critically Appraised Topic Source Type: research
AbstractSystemic lupus erythematosus (SLE) is a significant risk factor for cardiovascular disease. The relationship between SLE and perioperative cardiovascular risks following non-cardiac surgery is uncertain. We investigated associations between a diagnosis of SLE and outcomes following major non-cardiac surgery in a large national database from the United States. Patients age  ≥ 18 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project’s National Inpatient Sample data from 2004 to 2014. Systemic lupus erythematosus and perioperative major adver...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
We report the case of a 53‐year‐old female with an erythematous, papular eruption occurring in association with Hodgkin lymphoma. Histopathological evaluation of the rash confirmed PNGD. To the best of our knowledge, this is the first case of PNGD occurring in association with Hodgkin lymphoma. Although extremely rare, underlying malignancy should be considered in patients with PNGD, particularly in individuals with constitutional symptoms and the absence of an obvious inflammatory etiology.
Source: Journal of Cutaneous Pathology - Category: Pathology Authors: Tags: CASE REPORT Source Type: research
This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Letter to Editor Source Type: research
Publication date: April 2018 Source:Research in Veterinary Science, Volume 117 Author(s): Federica Di Profio, Irene Melegari, Vittorio Sarchese, Serena Robetto, Sandra Bermudez Sanchez, Emanuele Carella, Riccardo Orusa, Patrizia Cavadini, Antonio Lavazza, Fulvio Marsilio, Vito Martella, Barbara Di Martino European brown hare syndrome virus (EBHSV) was detected in a faecal swab collected from a wolf carcass in Northern Italy. The full-length genome of the EBHSV WOLF/17/2016/ITA strain was determined. In the VP60 capsid gene, the wolf strain displayed the highest genetic identity (99.2–99.1% nucleotide and 99.6–...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
In this study, we compared the characteristics and bone histomorphometric findings between subtrochanteric and diaphyseal sites in patients with BP-associated AFFs. Nine women with BP-associated AFFs were recruited, including 3 with systemic lupus erythematosus, 2 with rheumatoid arthritis, 2 with primary osteoporosis, 1 with polymyalgia rheumatica, and 1 with sarcoidosis. Patients were divided into the subtrochanteric group (n = 5; average age, 52 years; BP treatment, 5.9 years) and the diaphyseal group (n = 4; average age, 77 years; BP treatment, 2.6 years). Compared with the diaphyseal group, the subtrochanteric group h...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
ConclusionGiven the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
ConclusionIn SLE patients with active disease, both the SF‐36 and LupusQoL are sensitive to change, reflecting both improvement and worsening. More importantly, the LupusQoL SLE‐specific domains (planning, burden to others, body image, and intimate relationships) were largely responsive to change.
Source: Arthritis Care and Research - Category: Rheumatology Authors: Tags: Original Article Source Type: research
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