Lupus Studies Point to Gut Microbes, EpigeneticsLupus Studies Point to Gut Microbes, Epigenetics

Intestinal 'microbiome' and epigenetic changes in gene expression might contribute to systemic lupus erythematosus and could offer new routes to therapy, new studies have suggested. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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Abstract 38-year-old married woman presented with multiple spontaneous painful ulcers that had involved both forearms for the previous month, along with a single episode of generalized tonic-clonic seizures, with no residual palsy or paresis. She complained of photosensitivity and diffuse hair loss for the past 6 months. She also had had arthralgia for the previous 3 years, which had initially involved the small joints of the fingers (especially the proximal interphalangeal joints) and gradually progressed to involve the larger joints. There was no history of recurrent oral ulcers, psychosis, thromboembolic events...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
Nichole Woodward, 27, of Nebraska developed lupus suddenly five years ago, losing her hair, nearly 20lbs and going in to heart and kidney failure. Now, her autoimmune disease is at last under control.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(MedPage Today) -- But further analyses planned because of " provocative " findings
Source: MedPage Today Rheumatology - Category: Rheumatology Source Type: news
Conditions:   Lupus Erythematosus;   Stem Cell Transplant Intervention:   Biological: mesenchymal stem cells Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Maira Giannelou, Dimitrios Tseronis, Eleni Antypa, Clio P. Mavragani
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Semin Thromb Hemost DOI: 10.1055/s-0038-1648232The involvement of the hemostatic system in immune-mediated inflammation is widely reported. Many coagulation factors play a role in the pathogenesis of autoimmune diseases, such as systemic vasculitis and systemic lupus erythematosus. Hemostatic disorders are also involved in asthma and chronic spontaneous urticaria (CSU). Factor XIIa (FXIIa) was one of the first coagulation factors implicated in inducing both humoral and cellular responses and is therefore considered a prime new therapeutic target in immune-mediated inflammation. The involvement of coagulation factors, such ...
Source: Seminars in Thrombosis and Hemostasis - Category: Hematology Authors: Tags: Review Article Source Type: research
Conclusions With inclusion of LAC, the ELISA and CIA show comparable performance for the diagnosis of APS. However, correlations of APS-specific manifestations were dependent on method of detecting the aPL antibodies suggesting platforms may not be used interchangeable.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
A woman with cystic fibrosis and lung transplants suffered chronic pain for three years after she had a tattoo on her thighGetting a tattoo if you have a weakened immune system could put you at risk of complications, doctors have warned. The caution comes after a woman with cystic fibrosis and lung transplants developed thigh and knee pain after having body art inked on her leg.Doctors say those taking immunosuppressant drugs should take precautions if considering body art. These medicines are often given after an organ transplant or to treat autoimmune conditions such as Crohn ’s disease, lupus or rheumatoid arthrit...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Tattoos Medical research Immunology Biochemistry and molecular biology Health Cystic fibrosis Diabetes Source Type: news
Two UAB researchers have received Novel Research grants from the Lupus Research Alliance.   The grants, which total $100,000 for up to three years, were awarded to Andre Ballesteros-Tato and Frances Lund. The grants are aimed toward developing targeting treatments for lupus, a complex auto-immune disorder that has widespread and varied effects throughout the body. The professors are two of nine researchers nationwide who were awarded these grants to explore lupus from many different perspectives…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
AbstractAnti-U1-RNP positivity remains mandatory for the mixed connective tissue disease (MCTD) diagnosis, reason for which anti-U1-RNP occurrence in patients with lupus clinical features might determine diagnostic issues. Thus, the prevalence of 25 –30% for anti-RNP was reported in John Hopkins and LUMINA lupus cohorts and also 13% prevalence for the anti-U1-RNP in Euro-Lupus cohort. Presence of anti-U1-RNP antibodies in patients fulfilling SLE criteria (but not the MCTD ones) was associated with manifestations such as Raynaud phenomenon, mu sculoskeletal and lung impairment or nail fold capillaroscopy changes, some...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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