Lupus Studies Point to Gut Microbes, EpigeneticsLupus Studies Point to Gut Microbes, Epigenetics

Intestinal 'microbiome' and epigenetic changes in gene expression might contribute to systemic lupus erythematosus and could offer new routes to therapy, new studies have suggested. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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You're reading A Wee Wiggle in my Journey to Family, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Many of us have faced depression, struggled with low self-esteem, and other debilitating mental health challenges. My own journey with depression was a result of growing up with a rare blood disorder and being told I could never have children of my own. This completely changed my dreams of what family and life meant. Years later I suffered with a rare soft tissue sarcoma, yet, baffling the best of doctors, I survived. I&rs...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression featured psychology self improvement best books Donna Grant Wilcox faith family mental health pickthebrain Source Type: blogs
Conclusion Thematernal-fetal outcome is worse in SLE when thewomen experience a flare during pregnancy. The best maternal-fetal outcomes occur when the disease is in remission for at least 6 months befor e the pregnancy.Resumo Objetivo Avaliar os efeitos da gravidez em pacientes com l úpus eritematoso sistêmico (LES). Métodos Estudo de coorte retrospectivo. Os dados foram coletados de prontuários de mulheres com LES que engravidaram de janeiro de 2002 a dezembro de 2012 na Universidade Estadual de Campinas, São Paulo, Brasil. Lúpus eritematoso sistêmico e atividade da do en&cc...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
This study included 45 lupus patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria: 25 patients with active LN during activity and during follow up (3 months later) as [group A] and 20 patients without any signs of activity [group B]. (20) age and sex matched healthy subjects were enrolled as control group [group C]. Urine samples were collected at baseline and at follow up. Urinary IP-10 and sCD25 were measured by ELISA.ResultsUrinary IP-10 and sCD25 levels were higher in group A compared to groups B and C (P 
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
Abstract Young competitive athletes ( ≤ 35 years old) with or without a previous diagnosis of cardiovascular disease may suddenly die in competitive activities, potentially leading to an impact in society through the media. Although the relative risk for sudden death (SD) in athletes is twice as high as for their counterparts, the absolute incidence is low. While there is consensus among medical societies worldwide that early detection of causal factors is highly desirable, there is debate among different screening schemes to that end. In Brazil, the recommendations of the Brazilian Society of Cardiology mirror the guid...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 12 December 2018Source: Life SciencesAuthor(s): Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd. Asif Ansari, Abul Kalam Najmi, Syed Mansoor Ali, Javed Ali, Syed Ehtaishamul HaqueAbstractCyclophosphamide (CP) is an important anticancer drug which belongs to the class of alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation, rheumatoid arthritis, lupus erythematosus, multiple sclerosis, neuroblastoma and other types of cancer. Dose-related cardiotoxicity is a limiting factor for its use. CP-induced cardiotoxicity ranges from 7 to 28% and mortality ranges...
Source: Life Sciences - Category: Biology Source Type: research
Optic neuropathy is an uncommon finding in dialysis patients and has been associated with uremia, ischemia (arteritic and nonarteritic), drugs (isoniazid, ethambutol), infections (tuberculosis), and intracranial hypertension. Inflammatory optic neuritis associated with lupus is relatively rare, but clinicians need to be aware of this condition and obtain urgent ophthalmology consultation. Key Clinical MessageOptic neuropathy is an uncommon finding in dialysis patients and has been associated with uremia, ischemia (arteritic and nonarteritic), drugs (isoniazid, ethambutol), infections (tuberculosis), and intracranial hypert...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CLINICAL IMAGE Source Type: research
ConclusionIn SLE patients, homocysteine levels predicted damage accrual independently of other well-known risk factors for such occurrence.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionR-C4d is helpful to monitor early disease activity and PC4-d may be an important tool to detect a prothrombotic phenotype in SLE. Elevated levels of D-dimer and thrombomodulin add value to P-C4d data and corroborate a hypercoagulable profile in women with SLE, contributing to an increased prothrombotic risk associated with inflammation.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
(MedPage Today) -- Overall risks increased for both women and men, in particular in lymphatic and blood cancers, among others.
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
Condition:   Lupus Erythematosus, Systemic Interventions:   Drug: BI 705564;   Drug: Placebo Sponsor:   Boehringer Ingelheim Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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