4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling.

CONCLUSIONS: 4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling partly, which could be regarded as novel opportunities for treatment of insulin resistance.
PMID: 28153729 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - January 29, 2017 Category: Biochemistry Authors: Guo Q, Xu L, Li H, Sun H, Wu S, Zhou B Tags: Biochem Biophys Res Commun Source Type: research