Aberrant expression of CD227 is correlated with tumor characteristics and invasiveness of breast carcinoma.

CONCLUSIONS: We conclude that the aberrant expression of CD227, especially cytoplasm staining could be predictive for tumor aggressiveness, lymph node metastasis, poorer outcome of patients with breast cancers. And CD227 could promote the invasion ability of breast cancer cells, suggesting a potential role of CD227 as an oncogene in breast carcinoma.
PMID: 24788565 [PubMed - as supplied by publisher]

Source: Clinical Breast Cancer - May 1, 2014 Category: Cancer & Oncology Authors: Wang YW, Shi DB, Liu YM, Sun YL, Chen X, Xiang S, Fu Q, Wei JM, Gao P Tags: J Cancer Res Clin Oncol Source Type: research