Oxytocin: its role in the benign prostatic hyperplasia (BPH) via the ERK pathway

Conclusions: Oxytocin is highly expressed in the serum and prostate tissue of BPH patients. Additionally, oxytocin aggravates BPH and the oxytocin-induced proliferative effect on prostatic cells is mediated through MEK-ERK-RSK pathway, at least partly. Thus, hypothalamic regulation may be involved in BPH development, which may open a novel door for more medications for BPH in the future.

Source: Clinical Science - January 26, 2017 Category: Biomedical Science Authors: Xu, H., Fu, S., Chen, Y., Chen, Q., Gu, M., Liu, C., Qiao, Z., Zhou, J., Wang, Z. Tags: PublishAheadOfPrint Source Type: research