Relationship between Physicochemical Properties of Medical Supplies and Serious Adverse Drug Reactions Listed in the Package Inserts.

Relationship between Physicochemical Properties of Medical Supplies and Serious Adverse Drug Reactions Listed in the Package Inserts. Yakugaku Zasshi. 2017 Jan 13;: Authors: Yano R, Ohtsu F, Goto N Abstract <bibitem lang="en">  We sought to clarify the relationship between the physicochemical properties of each medical supply and serious adverse drug reactions listed in the package inserts, by reviewing new information. We investigated 1) 1,078 medicines currently available on the domestic Japanese market by using physicochemical data, such as cLogD, molecular weight (MW), and pKa and 2) the serious adverse drug reactions stated in the package inserts and the presence or absence of serious renal and liver disorders, as well as mental, extrapyramidal, and skin disorders. The renal disorders data showed: cLogD < 0, adjusted odds ratio (aOR) = 2.00; MW values ≥ 500, aOR = 2.28; and pKa < 7.4, aOR = 1.95 - 2.06. The liver disorders data showed: pKa < 8.4, aOR = 1.83 - 1.95, and MW values ≥ 300, aOR = 1.47 - 1.87. The mental disorders data showed: cLogD ≥ 0, aOR = 2.12, and MW values < 400, aOR = 2.46 - 2.85. The extrapyramidal disorders data showed: pKa ≥ 6.4, aOR = 4.50 - 11.32; cLogD ≥ 0, aOR = 4.71; and MW values < 500, aOR = 7.95 - 15.08. The skin disorders data showed: cLogD < 0, aOR = 1.46; MW values ≥ 500, aOR = 1.69; and pKa < 6.4, aOR = 1.65 or < 7.4 - 8.4, aOR = 1.59. This information...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research