Randomised, double-blind, clinical investigation to compare orlistat 60 milligram and a customized polyglucosamine, two treatment methods for the management of overweight and obesity

ConclusionsEven though both groups were instructed to adopt a calorie restricted diet together with increased physical activity an additional weight loss in the polyglucosamine group of 1.6 kilogram (kg) compared to the orlistat group (6.2  ± 3.46 versus 4.6 ± 2.36 kg) in both centers was seen despite the higher consumption of carbohydrates in Italy (center 2). A typical Italian diet is usually high in carbohydrate content whereas Germans tend to consume meals with higher fat content. This leads to the assumption that polygl ucosamine limits both fat and carbohydrate absorption which would explain the comparable effective weight reduction in the Italian participants.Trial registrationTrial registration at ClinicalTrials.govNCT02529631, registered on Aug 19, 2015 retrospectively registered.
Source: BMC Obesity - Category: Eating Disorders and Weight Management Source Type: research