Antimicrobial Susceptibility of Gram-Negative ESKAPE Pathogens Isolated from Hospitalized Patients with Intra-Abdominal and Urinary Tract Infections in Asia-Pacific Countries: SMART 2013-2015.

Antimicrobial Susceptibility of Gram-Negative ESKAPE Pathogens Isolated from Hospitalized Patients with Intra-Abdominal and Urinary Tract Infections in Asia-Pacific Countries: SMART 2013-2015. J Med Microbiol. 2017 Jan 03;: Authors: Karlowsky JA, Hoban DJ, Hackel MA, Lob S, Sahm DF Abstract Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) are responsible for increases in antimicrobial-resistant infections worldwide. We determined in vitro susceptibilities to eight parenteral antimicrobial agents using CLSI broth microdilution methodology for gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal infections (IAI) (n = 3,052) and urinary tract infections (UTI) (n = 1,088) in 11 countries/regions from 2013-2015. Amikacin (98.3%, 96.4%), imipenem (97.1%, 95.5%), and ertapenem (95.3%, 93.2%) demonstrated the highest rates of susceptibility for isolates of K. pneumoniae from IAI and UTI, respectively, whereas susceptibility to advanced-generation cephalosporins was <84% and <71%, respectively. K. pneumoniae with an ESBL-positive phenotype were more common in UTI (27.1%) than IAI (16.2%). Imipenem and amikacin were the most active agents against ESBL-positive K. pneumoniae from IAI (95.1%, 91.8%) and UTI (94.9%, 92.3%), respectively; whereas <54% were susceptible to piperacillin-tazobactam. Against Enterobacter spp. and P....
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research