Therapeutic modulation of Notch signalling — are we there yet?

Nature Reviews Drug Discovery 13, 357 (2014). doi:10.1038/nrd4252 Authors: Emma R. Andersson & Urban Lendahl The Notch signalling pathway is evolutionarily conserved and is crucial for the development and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases, such as T cell leukaemia, Alagille syndrome and a stroke and dementia syndrome known as CADASIL, and so strategies to
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research