After TOPCAT: What to Do in HF With Preserved EF After TOPCAT: What to Do in HF With Preserved EF

The results of the TOPCAT trial of spironolactone for heart failure with preserved ejection fraction showed little advantage over placebo. So where does that leave clinical management?European Heart Journal
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

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Authors: Chialà O, Vellone E, Klompstra L, Ortali GA, Strömberg A, Jaarsma T Abstract OBJECTIVES: To describe the relationships among 3 measures of physical fitness (exercise capacity, muscle function and functional capacity) in patients with heart failure, and to determine whether these measures are influenced by impairment of movement. METHODS: Secondary analysis of baseline data from the Italian subsample (n = 96) of patients with heart failure enrolled in a randomized controlled trial, the HF-Wii study. Exercise capacity was measured with the 6-min walk test, muscle function was me...
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Publication date: Available online 25 June 2019Source: Journal of the Saudi Heart AssociationAuthor(s): Waleed AlHabeeb, Fakhr Al-Ayoubi, Kamal AIGhalayini, Fahad Al Ghofaili, Yahya Al Hebaishi, Abdulrazaq Al-Jazairi, Mouaz H. Al-Mallah, Ali AlMasood, Maryam Al Qaseer, Shukri Al-Saif, Ammar Chaudhary, Abdelfatah Elasfar, Adel Tash, Mohamed Arafa, Walid HassanAbstractHeart failure (HF) is the leading cause of morbidity and mortality worldwide and negatively impacts quality of life, healthcare costs, and longevity. Although data on HF in the Arab population is scarce, recently developed regional registries are a step forward...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
The hybrid assistive limb (HAL) provides motion assistance based on bioelectrical signals detected on the skin surface when muscle forces are generated. The lumbar-type HAL is expected to expand the therapeutic options for severe cardiac patients who have difficulty in moving on their own legs. We aim to compare the efficacy of exercise therapy performed with assistance from a lumbar-type HAL versus conventional training (sit-to-stand exercise without HAL) in patients with chronic heart failure. This investigation will be a randomized, nonblinded, controlled study. Sixty patients who satisfy the criteria to receive cardiac...
Source: Cardiology - Category: Cardiology Source Type: research
Conclusion: A significant association between mild to moderate impairment of renal function and echocardiographic markers of cardiac structure and diastolic function was observed, supporting the hypothesis that interaction between the kidney and heart exists even in the early stages of renal impairment.Cardiorenal Med
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
Conclusion: CRS type 1 patients present with an increased level of LPS and there is a direct correlation between LPS and renal parameters. This pilot research is the first study to explore the premise of LPS as novel pathophysiological factor in CRS type 1.Cardiorenal Med
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
Conclusion: GFR-specific risk-based cutoffs for PTH1 –84 and FGF-23 may facilitate more meaningful risk stratification in advanced CKD than current GFR-agnostic reference ranges derived from healthy adults. This may be most applicable in those with severely reduced GFR.Am J Nephrol
Source: American Journal of Nephrology - Category: Neurology Source Type: research
Publication date: Available online 3 June 2019Source: Indian Heart JournalAuthor(s): Raymond Pranata, Emir Yonas, Veresa Chintya, Amir Aziz Alkatiri, Bambang Budi SiswantoAbstractBackgroundBendopnea is a symptom mediated by increased ventricular filling pressure during bending forward. Presence of bendopnea in patients can be easily evaluated without additional maneuver in several countries whose norms, habits, culture, and occupation relates to a higher frequency of bending forward. This information may prove valuable in routine clinical practice. We aimed to analyze the latest evidence on bendopnea in order to further de...
Source: Indian Heart Journal - Category: Cardiology Source Type: research
AbstractPurpose of ReviewIn this review, we discuss risk assessment of advanced heart failure (HF) patients as a referral guide for advanced HF therapies, including left ventricular assist device (LVAD) support and cardiac transplant.Recent FindingsThe frequency of LVAD implantation for the purpose of permanent “destination” therapy is growing and survival on LVAD support is now approximating 50% at 5 years. Ambulatory HF patients with HF functional limitations, end-organ dysfunction, inability to tolerate HF medications, frequent cardiac admissions, and ventricular dysrhythmias are at high risk for m orta...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to provide a comprehensive update on recent advances in heart transplantation.Recent FindingsHeart transplantation is now an established therapy for end-stage heart failure, though challenges still exist. However, multiple advances over the past few years will improve the survival and quality of life of heart transplant recipients. These advances include acceptance of previously considered marginal donor hearts, revisions to the donor heart allocation policy, advances in desensitization regimens, tailoring of immunosuppression regimens, and improvement in the diagnosis...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
AbstractDapagliflozin (Forxiga®) is a highly potent, reversible and selective sodium-glucose cotransporter-2 inhibitor indicated worldwide for the treatment of type 2 diabetes (T2D). In the EU, oral dapagliflozin once daily is approved for use as monotherapy (in patients who are intolerant of metformin) and as add-on combination therapy (with other glucose-lowering agents, including insulin) for T2D when diet and exercise alone do not provide adequate glycaemic control. In numerous well-designed clinical studies and their extensions, dapagliflozin as monotherapy and combination therapy with other antihyperglycaemic age...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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