Co-occurring mutations of tumor suppressor genes, LATS2 and NF2, in malignant pleural mesothelioma.

CONCLUSIONS: We identified a new MPM molecular subgroup that shares common genetic and transcriptomic characteristics. Our results made it possible to highlight a greater sensitivity to an anticancer compound for this MPM subgroup and to identify a specific potential biomarker. PMID: 28003305 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28003305?dopt=Abstract

Source: Clinical Cancer Research - December 20, 2016 Category: Cancer & Oncology Authors: Tranchant R, Quetel L, Tallet A, Meiller C, Renier A, de Koning L, de Reyniès A, Le Pimpec Barthes F, Zucman-Rossi J, Jaurand MC, Jean D Tags: Clin Cancer Res Source Type: research