Meta-Analysis for Penalized Regression Methods with Multi-Cohort Genome-Wide Association Studies

Conclusion: After comparing the three methods that we proposed to conduct meta-analysis, we recommend splitting cohorts rather than datasets to obtain valid p values for meta-analysis of results from penalized regression in multi-cohort setting.Hum Hered 2016;81:142-149

Source: Human Heredity - December 21, 2016 Category: Genetics & Stem Cells Source Type: research