Incontinence in persons with Angelman syndrome

Conclusion: Children with AS have high rates of incontinence. Many adults are still affected by NE, DUI, or even FI. Screening, assessment, and treatment of incontinence in individuals with AS are recommended.What is Known:•Incontinence in persons with Angelman syndrome (AS) is associated with younger age, lower level of adaptive functioning, and epilepsy.What is New:•Children and teens with AS are at special risk for incontinence, but older persons are also affected.•Comorbid epilepsy is significantly associated not only with nocturnal enuresis (NE) but also with daytime urinary incontinence (DUI). Underlying genotype is significantly associated with incontinence.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research