Abstract B28: FKBP6 gene is involved in progression of cervical cancer

Conclusions: There is a FKBP6 dysregulation in CC cell lines, and the inactivation mechanism seems to be methylation. Restored expression of FKBP6 in SiHa cell line modifies the tumor phenotype, decreasing colony formation, but increasing cell viability. These results suggest that FKBP6 could be implied in cervical progression, but more studies are necessary to evaluate FKBP6 functions in cervical cancer.Acknowledgments: FONDECYT N°3130630, Project Corfo N° 09CN14-5960, Project Corfo N°12IDL2-18157. Project FONDECYT N° 11150802, Project FONDECYT N°1115062Citation Format: Carmen Gloria Ili, Tamara Viscarra, Juan Carlos Araya, Jaime Lopez, Barbara Mora, Javier Retamal, Susana Aedo, Enrique Bellolio, Juan Carlos Roa, Priscilla Brebi. FKBP6 gene is involved in progression of cervical cancer. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Cancer Cell Cycle - Tumor Progression and Therapeutic Response; Feb 28-Mar 2, 2016; Orlando, FL. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(11_Suppl):Abstract nr B28.

Source: Molecular Cancer Research - November 9, 2016 Category: Cancer & Oncology Authors: Ili, C. G., Viscarra, T., Araya, J. C., Lopez, J., Mora, B., Retamal, J., Aedo, S., Bellolio, E., Roa, J. C., Brebi, P. Tags: Other Topics: Poster Presentations - Proffered Abstracts Source Type: research