Three new labdane diterpenes from Loxocalyx urticifolius

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Min Zhao, Da-Le Guo, Lv-Yi Yuan, Yu-Cheng Gu, Lei Chen, Li-Sheng Ding, Yan Zhou Three new labdane diterpenes, namely loxocalyxin D (1), loxocalyxin E (2) and 13-epiloxocalyxin E (3), were isolated from the whole plants of Loxocalyx urticifolius Hemsl. Their structures were elucidated by extensive spectral analysis and chemical methods. The absolute configuration of loxocalyxin D (1) was confirmed by X-ray crystallographic analysis. The cytotoxic activities of the isolated labdane diterpenes were evaluated against the four human cancer cell lines A549, HepG2, HL-60 and MCF-7. 13-epiloxocalyxin E (3) exhibited selective cytotoxicity against A549 and MCF-7 with the IC50 values of 22.4 and 47.3μM, respectively. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research