Analysis of correlation between pediatric asthma exacerbation and exposure to pollutant mixtures with association rule mining

Conclusions The proposed method can be used to analyze risk variations caused by single and multiple exposures. The method is reliable and requires fewer assumptions on the data than parametric approaches. Rules including more than one pollutant highlight interactions that deserve further investigation, while helping to limit the search field.
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research

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ConclusionsThis study showed the association between some environmental factors with the odds of having asthma. These factors can be considered in primary prevention programs for asthma.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Authors: Salhi M, Lahmar O, Salah MO, Banić I, Binghao B, Malik W, Hamzaoui K, Turkalj M, Hamzaoui A Abstract OBJECTIVE: Pharmacogenetic studies have recognized specific genes that highly correlate with response to inhaled corticosteroids (ICS) treatment in asthma patients. Among the genes identified, we selected glucocorticoid-induced transcript 1 (GLCCI1) and stress-induced phosphoprotein 1 (STIP1) to evaluate the impact of these gene polymorphisms on ICS treatment response in Tunisian asthmatics. METHODS: We analyzed four single nucleotide polymorphisms (SNPs): two in GLCCI1 (rs37972 and rs37973), and two i...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Kong I, Zhao Y, Wang Y, Chang X, Cui L, Gu G, Ma Z, Lu Q, Zhou L, Ding L, Wang Z, Shao Y, Tang H, Zhang C, Hui F, Mei X, Xin J, Huo J, Sun S, Zhu S, Yao C, Du G, Cheng M, Kang J Abstract Purpose: The aim of this study was to investigate the efficacy and safety of tratinterol hydrochloride in bronchial asthma(BA) treatment. Methods: Patients enrolled in this study were distributed randomly into a treatment group (tratinterol hydrochloride) and an active control group (procaterol hydrochloride) and were treated for 2 weeks after running-in. The end points were changes in pulmonary function and clinical sympt...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
A reader asks DR ELLIE CANNON of ways to keep fit which will not worsen the symptoms of their asthma which makes them wheeze when they take part in exercise.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 12 September 2019Source: The LancetAuthor(s): R Sharon Chinthrajah, Natasha Purington, Sandra Andorf, Andrew Long, Katherine L O'Laughlin, Shu Chen Lyu, Monali Manohar, Scott D Boyd, Robert Tibshirani, Holden Maecker, Marshall Plaut, Kaori Mukai, Mindy Tsai, Manisha Desai, Stephen J Galli, Kari C NadeauSummaryBackgroundDietary avoidance is recommended for peanut allergies. We evaluated the sustained effects of peanut allergy oral immunotherapy (OIT) in a randomised long-term study in adults and children.MethodsIn this randomised, double-blind, placebo-controlled, phase 2 study, we enrolle...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionThere is moderate evidence that high doses of ICS, in addition to SCS, reduces the risk of hospital admission in ED treatment of moderate to severe asthma exacerbations. Further research is required to determine their optimal role in both ED and outpatient settings.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jonathan Corren, Mario Castro, Thomas O’Riordan, Nicola A. Hanania, Ian D. Pavord, Santiago Quirce, Bradley E. Chipps, Sally E. Wenzel, Karthinathan Thangavelu, Megan S. Rice, Sivan Harel, Alexandre Jagerschmidt, Asif Khan, Siddhesh Kamat, Jaman Maroni, Paul Rowe, Yufang Lu, Nikhil Amin, Gianluca Pirozzi, Marcella RuddyAbstractBackgroundDupilumab blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation, including immunoglobulin E (IgE)-m...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Jin Shang, Weihua Liu, Chunyan Yin, Haiping Chu, Meizhen ZhangAbstractAsthma is a chronic inflammatory disorder of airway affecting people from childhood to old age, and is characterized by airway epithelial dysfunction. Cucurbitacin E (CuE), a tetracyclic triterpene isolated from Cucurbitaceae plants, has been recently proved to exert anti-inflammation and immunology regulation activities. Nevertheless, its roles in asthma remains poorly defined. In the current study, CuE had little cytotoxicity on cell viability of human bronchial epithelial...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, the findings of this study suggest that excess body weight could impact pulmonary dynamics in childhood asthma.
Source: Lung - Category: Respiratory Medicine Source Type: research
AbstractPurpose of ReviewUrbanization and urbanization-related detrimental exposures are commonly indicated as responsible determinants for the dramatic increase in allergy and asthma, and one of the main urbanization factors that have been recently associated with the development of allergic sensitization is the reduced access to natural and biodiverse spaces. The present review aimed to compile and discuss the recent findings from studies focused on neighbourhood greenspace effect on asthma and allergic disease development in children.Recent FindingsGreen areas neighbouring children residences play a role on the prevalen...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
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