Change in IGHV Mutational Status of CLL Suggests Origin from Multiple Clones

Current clinical CLL grading systems poorly predict overall survival and disease aggressiveness, especially in early stage patients. (1) Among the independent molecular-based CLL prognostic markers, interphase fluorescence in-situ hybridization (FISH) DNA analysis and immunoglobulin variable region heavy chain (IGHV) mutational status are the most predictive. (2, 3) There is growing evidence that compared to FISH analysis, IGHV mutational sequence status better discriminates for overall survival.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research