Comment Unravelling mucosal immunity to poliovirus

From an immunological perspective, the battle to eradicate polio is one of blood and guts. Induction of circulating poliovirus antibodies in blood is essential to block the spread of viruses to the CNS and thereby protect against paralytic disease. However, as eradication draws closer, the induction of immunity in the gut mucosa is becoming an ever-greater concern. Mucosal immunity is key to halting the spread of poliovirus from person to person, and thereby condemning the virus to extinction.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Comment Source Type: research

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Publication date: Available online 12 December 2019Source: BiologicalsAuthor(s): Hebleen Brenes, Gilbert D. Loría, Bruno LomonteAbstractSecreted phospholipase A2 (sPLA2) molecules are small, calcium-dependent enzymes involved in many biological processes. Viperid venoms possess gIIA sPLA2s and sPLA2-like proteins, both having homology to human gIIA sPLA2, an innate immunity enzyme. We evaluated the antiviral action of Mt–I (catalytically-active sPLA2) and Mt-II (catalytically-inactive variant) isolated from the venom of Bothrops asper, against a diverse group of viruses. Yellow Fever and Dengue (enveloped) vir...
Source: Biologicals - Category: Biology Source Type: research
Chronic obstructive pulmonary disease (COPD) has few treatment options, with patients frequently experiencing shortness of breath. To address this most unwelcome symptom of COPD, Dr. Jake Brenner, a critical care physician specializing in pulmonology...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Critical Care Source Type: blogs
THURSDAY, Dec. 12, 2019 -- Last October, 15-year-old Alec Woodruff developed a strange-sounding cough. Less than a week later, he was fighting for his life in the hospital, partially paralyzed and with a tube in his throat attached to a ventilator...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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Source: Angewandte Chemie - Category: Chemistry Tags: Angew Chem Int Ed Engl Source Type: research
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Source: NIH Calendar of Events - Category: American Health Source Type: events
A 3-month-old Malaysian infant has been diagnosed with polio, the first case reported in the country in nearly three decades, a top health official said on Sunday.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Infectious Diseases News Source Type: news
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Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(Natural News) Many people still believe today that Dr. Jonas Salk was the “God” of cult pharmacology because he invented the polio vaccine. But did he? In actuality, all he did was conduct illegal medical experiments on mental patients, while the steady decline of mortality from infectious diseases was instantly (and falsely) credited to him...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
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Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
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