PAVmed partners with Boston institutions for antibiotic-eluting ear device
PAVmed Inc. (NSDQ:PAVMU) said today that it inked an exclusive licensing agreement with academic institutions to develop and commercialize antibiotic-eluting resorbable ear tubes based on an aqueous silk technology designed by the institutions. The licensing deal includes agreements with Tufts University, Massachusetts Eye &Ear Infirmary and Massachusetts General Hospital, who developed the aqueous silk technology. As many as 1 million children annually undergo pediatric surgery to place metal, plastic, or latex bilateral ear tubes to ventilate and drain the middle ear as a means to relieve persistent ear infections (otitis media) or middle ear fluid collections (effusions), the company said. The procedure is the most common pediatric surgical procedure in the U.S., according to PAVmed. Get the full story at our sister site, Drug Delivery Business News. The post PAVmed partners with Boston institutions for antibiotic-eluting ear device appeared first on MassDevice.
Publication date: Available online 13 June 2019Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): F. Carré, S. Achard, I. Rouillon, M. Parodi, N. LoundonAbstractThe goal is to clarify the epidemiology of hearing loss in patients with osteogenesis imperfecta (OI), so as to improve management. A literature review analyzed data from 15 patient series. Hearing loss prevalence in OI varied widely, from 2% to 94.1%. Typically, hearing loss was conductive in young patients and sensorineural in older patients. Prevalence increased with age, but after 50 years the increase was slight, and seldom...
Conclusion: While the exact role of intratympanic injections requires additional trials, triamcinolone resulted in similar outcomes compared to studies using dexamethasone or methylprednisolone. Due to favorable pharmacological properties, triamcinolone represents a safe and efficacious alternative for intratympanic treatment in idiopathic sensorineural hearing loss.
Conclusions: Data from the current study suggest that canalplasty offers benefit regarding closure rate in medial graft tympanoplasty. Use of cartilage also portended a higher rate of perforation closure. Canalplasty should be considered when using medial graft techniques if exposure is limited due to bony canal anatomy.
Conclusion: Neglected mastoid cavity care, low socioeconomic status, poor personal hygiene, homelessness, and chronic suppurative otitis media are likely contributing factors to this uncommon presentation occurring in an urban setting.
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DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dyspha...
ConclusionBET combined with TTI surgery is an effective therapy for patients with CRSOM.
Authors: Kazdaglis G, Lucin J, Kertat K, Persis S Abstract Streptococcus pneumoniae is a Gram-positive, alpha-hemolytic, facultative anaerobic coccus. It is the most common cause of community acquired pneumonia in adults and infants, and a major cause of morbidity and mortality. It is also a frequent cause of otitis media and sinus infections. It spreads through close person-to-person contact via respiratory droplets. It presents as pneumonia, bacteremia, or meningitis. PMID: 31184099 [PubMed - as supplied by publisher]
We report a rare case of a nine-month-old infant who showed right temporal mass with no evidence of infection. Computed tomography showed an osteolytic round mass, and magnetic resonance imaging revealed heterogenous enhancement with a high apparent diffusion coefficient. Malignant tumor was first suspected, but an open biopsy revealed the swelling to be temporal muscle abscess. It should be noted that temporal abscess may mimic the features of a malignant tumor, and multiple examinations should be performed for an accurate diagnosis. PMID: 31178474 [PubMed - as supplied by publisher]