Levels of nitric oxide pathway parameters may depend on heteroplasmy rates of the m.3243A > G mutation

Concerning the article by Hanff et al. about L-arginine/nitric-oxide(NO)-pathway and arginine:glycine-amidinotransferase(AGAT) activities in a 57yo male with mitochondrial encephalopathy, lactacidosis, and stroke-like-episode(MELAS)-syndrome due to the m.3243A>G mutation [1]. we raise the following concerns.

Source: International Journal of Cardiology - November 3, 2016 Category: Cardiology Authors: Josef Finsterer, Sinda Zarrouk-Mahjoub Source Type: research