Impaired thiol-disulphide balance in acute brucellosis.

The objective of this study was to examine a novel profile: thiol-disulphide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulphide profile tests were analysed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 ± 48.20 µmol/L in the acute brucellosis group and 461.13 ± 45.37 µmol/L in the healthy group, and total thiol levels were 298.58 ± 51.78 µmol/L in the acute brucellosis group and 504.83 ± 51.05 µmol/L in the healthy group (p < 0.001, for both). The disulphide/native thiol ratios and disulphide/total thiol ratios were significantly higher, and native thiol/total thiol ratios were significantly lower, in patients with acute brucellosis than in the healthy controls (p < 0.001, for all ratios). There were positive or negative relationships between ceruloplasmin levels and thiol-disulphide parameters. The thiol-disulphide homeostasis was impaired in acute brucellosis. The strong associations between thiol-disulphide parameters and a positive acute-phase reactant reflected the disruption of the balance between the antioxidant and oxidant systems. Because thiol groups act as anti-inflammatory mediators, the alteration in the thiol-disulphide homeostasis may be involved in brucellosis. PMID: 27795469 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research