[Cerebrospinal fluid diagnostics in multiple sclerosis].

[Cerebrospinal fluid diagnostics in multiple sclerosis].
Nervenarzt. 2016 Sep 20;
Authors: Ruprecht K, Tumani H
Abstract
As a chronic inflammatory disease of the central nervous system (CNS), multiple sclerosis (MS) is associated with characteristic abnormalities in cerebrospinal fluid (CSF). Thus, in addition to magnetic resonance imaging, CSF examination is a central diagnostic procedure in patients with MS, which can corroborate a diagnosis of MS and may also help to discern differential diagnoses. The most important CSF finding in MS is the detection of persistent polyspecific intrathecal immunoglobulin synthesis. This review summarizes CSF findings of patients with MS and addresses issues of relevance for clinical practice, potential diagnostic pitfalls as well as new developments in CSF diagnostics of MS.
PMID: 27649986 [PubMed - as supplied by publisher]

Source: Der Nervenarzt - September 19, 2016 Category: Neurology Authors: Ruprecht K, Tumani H Tags: Nervenarzt Source Type: research