Epidemiology of acute animal bite and the direct cost of rabies vaccination

Conclusions The results of this study showed that due to the increasing incidence of animal bites and the financial burden resulting from animal bite vaccination, it is necessary to design and implement preventive measures in order to reduce the animal bites.
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research

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In this study, we generated two recombinant RABVs, rERAG333E/NiVG and rERAG333E/NiVF, expressing the NiV Malaysian strain attachment glycoprotein (NiV-G) or fusion glycoprotein (NiV-F) gene based on the rERAG333E vector platform. Both rERAG333E/NiVG and rERAG333E/NiVF displayed growth properties similar to those of rERAG333E and caused marked syncytia formation after co-infection in BSR cell culture. Adult and suckling mice intracerebrally inoculated with the recombinant RABVs showed NiV-G and NiV-F expression did not increase the virulence of rERAG333E. Oral vaccination with rERAG333E/NiVG either singularly or combined wi...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
This study showed that the immune fingerprint approach can be used to screen vaccine formulations. It provides additional information compared to classical vaccination and infectious challenge efficacy study.
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
​Fingertip injuries and amputations are common in the emergency department, often occurring on weekends when consultants are not available. Some experienced physicians may consider rongeuring distal tuft amputation injuries, but simple closure and expert consultation for more difficult cases are suggested.A fingertip amputation within zone III involving total amputation of the distal tip, fingernail, matrix, and tuft. Photos by M. Roberts.Care of fingertip amputations in the ED should focus on removing debris and cleaning the wound as best as possible, closing the wound using available skin, bandaging and splinting for c...
Source: The Procedural Pause - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
This article provides information on these and other travel vaccinations against hepatitis A, typhoid fever, rabies, Japanese encephalitis and cholera.Yellow fever endemic areas are located in Africa and in South America; there is no yellow fever in Asia. The meningococcal vaccine (A, C, W, Y) is required for pilgrims to Saudi Arabia. Additionally, it is recommended for travellers visiting the African "meningitis belt" during the dry season. A polio booster is required for countries with endemic wild-type polio virus (WPV) or circulating vaccine derived poliovirus (cVDPV).Hepatitis A is a common vaccine-prev...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - Category: International Medicine & Public Health Authors: Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
In conclusion, our results demonstrate that MPLA serving as an adjuvant enhances the intensity of humoral immune responses by activating the cDC–Tfh–GC B axis. Our findings will contribute to the improvement of the efficiency of traditional rabies vaccines.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Bruce A. Kimball, Steven F. Volker, Doreen L. Griffin, Shylo R. Johnson, Amy T. Gilbert Rabies is a zoonotic disease caused by infection with rabies virus, which circulates naturally in several wild carnivore and bat reservoirs in the United States (US). The most important reservoir in the US from an animal and public health perspective is the raccoon (Procyon lotor). To prevent the westward expansion of a significant raccoon rabies epizootic along the eastern seaboard, an operational control program implementing oral rabies vaccination (ORV) has existed in the US since the 1990s. Recently, two vaccine efficacy studies...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
AbstractDog demographics are considered as one of the main factors in the control of rabies. Having reliable data on dog population and husbandry practices on how they are managed is a key point in the elaboration of any control program to fight against human deaths due to rabies which are mainly due to dogs. However, the lack of data regarding dog population is one of the main hindrances to elaborate effective fighting projects in developing countries, particularly in Africa. In order to contribute for reliable data on dog demographics and husbandry practices related to rabies, this study was carried out in the cities of ...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Publication date: Available online 12 November 2019Source: Preventive Veterinary MedicineAuthor(s): Felipe Rocha, Ricardo Augusto DiasAbstractThe importance of the common vampire bat Desmodus rotundus for the transmission of the rabies virus does not lie solely in its ability to transmit this disease to other mammals, but also in its capacity to adapt to environmental and climatic changes, granting them a wide geographical distribution. Control of this disease is currently based on culling of the vampire bat and vaccination of the livestock. A transmission model incorporating geographic and behavioral determinants of the v...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
CONCORD, N.H. (AP) — New Hampshire health officials are requesting the public’s help in finding a man from Massachusetts to assess his risk for rabies after he came into contact with baby raccoons. Health officials say the man was in Conway at about 5 p.m. on Sept. 20 and stopped to help someone remove two baby raccoons on Route 16 between North Bald Hill Thorn Hill roads. The raccoons were brought to a wildlife rehabilitation center, where one died and was identified to have rabies. The other didn’t have rabies. Health officials said Friday the man, who drove a dark pickup truck with oversized tires and ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Offbeat Syndicated CBSN Boston New Hampshire News Rabies raccoons Source Type: news
In this study, we demonstrated that the three investigated bat isolates were pathogenic, even at low dose, when inoculated by the central route but were not/less pathogenic when administrated peripherally. The Rabisin vaccine was capable of significantly cross-protecting mice inoculated intramuscularly with EBLV-1b and EBLV-2 and intracerebrally with BBLV. The level of rabies neutralizing antibodies induced by the Rabisin was quite high against the bat lyssaviruses, but with no significant differences between immunization with 1 and 5 IU/dose. The study emphasizes that the quality of rabies-inactivated vaccines for veterin...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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