What Animal Models of Testicular Descent and Germ Cell Maturation Tell Us about the Mechanism in Humans

Eur J Pediatr Surg DOI: 10.1055/s-0036-1592196Testicular descent occurs in most mammals in two main steps that have different hormonal control and anatomical processes. The evolution of testicular descent reveals the same basic processes in humans and animals, with minor differences in timing and anatomy, especially the location of the scrotum and the processus vaginalis. Animal models are useful as they reveal some embryological processes that cannot be studies easily in humans, such as the potential role of the mammary line and the role of the genitofemoral nerve. Postnatal germ cell development is very similar in animal models and humans, except for the timing of arrival of the testis into the scrotum, which is before birth in humans versus around puberty in rodents. Once all the minor differences between animal models and humans are taken into account, animal experimentation has provided amazing insights into the mechanisms of testicular descent, and recently, how the postnatal germ cell develops in normally descended and undescended testes. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Review Article Source Type: research

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Abstract When a student explains a biological phenomenon, does the answer reflect only the product of retrieving knowledge or does it also reflect a dynamic process of constructing knowledge? To gain insight into students' dynamic knowledge, we leveraged three analytic frameworks-structures-behaviors-functions (SBF), mental models (MM), and conceptual dynamics (CD). To assess the stability of student knowledge, we asked undergraduate students to explain the same physiological phenomenon three times-once verbally, once after drawing, and once after interpreting a diagram. The SBF analysis illustrated fine-grained d...
Source: CBE Life Sciences Education - Category: Cytology Authors: Tags: CBE Life Sci Educ Source Type: research
Abstract As an instructional tool, models can transform the student experience from the static to the dynamic, the flat to the 3D, and the siloed to the integrated. Few practical resources exist to help instructors transition toward model-based classroom practices. The Modeling in the Classroom evidence-based teaching guide provides instructors with a tool kit for incorporating models and modeling into their classrooms (https://lse.ascb.org/evidence-based-teaching-guides/modeling-in-the-classroom). The guide discusses the underpinnings of modeling as a core scientific practice, one that can enable student developm...
Source: CBE Life Sciences Education - Category: Cytology Authors: Tags: CBE Life Sci Educ Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
Publication date: Available online 25 January 2020Source: MethodsAuthor(s): Prithwijit Sarkar, Noushin Akhavantabib, Sheena D'ArcyAbstractInteractions between histones and their binding partners are an important aspect of chromatin biology. Determining the stoichiometry of histone-containing complexes is an important pre-requisite for performing in vitro biochemical, biophysical and structural analyses. In this article, we detail how Size Exclusion Chromatography (SEC) coupled to Multi-Angle Light Scattering (MALS) can be used to study histone chaperones and their complexes. Our protocol details system setup, sample prepar...
Source: Methods - Category: Molecular Biology Source Type: research
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Source: Methods - Category: Molecular Biology Source Type: research
Publication date: Available online 25 January 2020Source: Journal of Molecular LiquidsAuthor(s): Tibor Liptaj, Ján Marták, Štefan SchlosserAbstractIonic liquids (ILs) have received substantial attention in basic and applied research in the last two decades. This work is focused on deeper understanding of carboxylic acids extraction by ILs with potential in recovery of platform chemicals from diluted streams in biorefineries. Results of an NMR study of structural changes of a system composed of trihexyl-(tetradecyl)-phosphonium decanoate, butyric acid (BA) and water are presented. 1H, 13C and 31P NMR we...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
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