Role of the Deubiquitinating Enzyme Ubiquitin-specific Protease-14 in Proteostasis in Renal Cells.
In conclusion, Usp14 controls proteasomal degradation of some misfolded proteins. In addition, a Usp14-directed inhibitor reduces cytotoxicity in the context of global protein misfolding during certain types of renal cell injury.
PMID: 27630065 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Sareen-Khanna K, Papillon J, Wing SS, Cybulsky AV Tags: Am J Physiol Renal Physiol Source Type: research