How sugar industry sweetened research in its favor
Scientists began to uncover a link between sugar and heart disease about 60 years ago, and now, the general consensus among experts is that sugar intake is associated with heart disease risk.
Authors: Dahal S, Budoff MJ Abstract The results of the ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approach) trial were presented at the American Heart Association Scientific Sessions in November, 2019 in Philadelphia, Pennsylvania, and recently published on March 30, 2020 in the New England Journal of Medicine. After an average follow-up of 3.5 years, invasive therapy did not reduce the major adverse cardiac event (MACE) rate compared with optimal medical therapy (OMT) in patients with stable ischemic heart disease. However, the ISCHEMIA trial results might stem fro...
Reduced expression of the key regulator of cardiac metabolism, transcription factor PPAR α, in surgical samples of the auricles from patients with coronary heart disease and heart failure was detected by real-time quantitative PCR. These changes indicate reduced activity of this factor and a shift of energy metabolism from oxidative phosphorylation to glycolysis typical of dedifferenti ated cells. Electron microscopy revealed dedifferentiated cardiomyocytes with disassembled contractile apparatus and disorganized sarcomeres. In the examined specimens from patients with heart failure, severe myocardial fibrosis was revealed.
Conclusion: MHR is significantly associated with CVD in COPD patients. Further prospective studies are warranted to elucidate the predictive value of MHR in COPD patients.
CONCLUSION: Current data imply that PCI for CCS does not improve outcomes in a large percentage of cases. A symptomatic benefit exists only in patients with frequent angina pectoris. The selection of CCS patients for PCI needs to be more strictly bound to the recommendations of current guidelines, particularly in Germany. PMID: 32234189 [PubMed - in process]
Publication date: Available online 2 April 2020Source: Revista Española de Cardiología (English Edition)Author(s): José María Oliver Ruiz, Laura Dos Subirá, Ana González García, Joaquín Rueda Soriano, Pablo Ávila Alonso, Pastora Gallego, on behalf of the Spanish Adult Congenital Heart Disease Network (RECCA)
Authors: Arita Y, Tanaka K, Kitabayashi K, Hasegawa S PMID: 32238728 [PubMed - as supplied by publisher]
EATING between three and six eggs a week improves heart health and lowers the risk of dying early, a study has revealed.
Conclusion: Amlodipine lowered long-term gout risk compared with lisinopril or chlorthalidone. This finding may be useful in cases where gout risk is a principal concern among patients being treated for hypertension. This trial is registered at clinicaltrials.gov, number: NCT00000542.
Mutations in GATA6 are the most frequent cause of pancreatic agenesis. Most cases present with neonatal diabetes mellitus.
DiscussionSevoflurane is the most frequently used anesthetic in young children, but has been indicated as an independent risk factor in the development of emergence delirium. Xenon and dexmedetomidine have both been associated with a reduction in the incidence of emergence delirium. Combining xenon and dexmedetomidine has never been described as a balanced-anesthesia technique in children. Our pilot study will therefore deliver important data required for future prospective clinical trials.Trial registrationEudraCT, 2018 –002258-56. Registered on 20 August 2018.https://www.clinicaltrialsregister.eu.