In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome

Conclusions
In summary, this first investigation of intrahost HEV population evolution indicates that RBV causes HEV mutagenesis in treated patients and that an emergence of distinct mutants within the viral population occurs during RBV therapy. We also suggest that next-generation sequencing could be useful to guide personalised antiviral strategies.

Source: Gut - September 7, 2016 Category: Gastroenterology Authors: Todt, D., Gisa, A., Radonic, A., Nitsche, A., Behrendt, P., Suneetha, P. V., Pischke, S., Bremer, B., Brown, R. J. P., Manns, M. P., Cornberg, M., Bock, C. T., Steinmann, E., Wedemeyer, H. Tags: Cirrhosis, Open access Hepatology Source Type: research